Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19003240 | 0.83 | MAPT (0.57) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL18985196 | 0.82 | RAB9A (0.54) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL19003232 | 0.78 | RAB9A (0.53) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL19003241 | 0.67 | TGM2 (0.52) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL19003245 | 0.66 | BCHE (0.58) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL19003252 | 0.66 | RAB9A (0.53) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL12790129 | 0.66 | KMT2A (0.64) | SMN1; SMN2RAB9AMAPTMEN1KMT2A | |
| SCHEMBL18985262 | 0.65 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL18985260 | 0.65 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL10788098 | 0.63 | LMNA (0.68) | SMN1; SMN2RAB9AMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017102014-A1 | PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE | UNIVERSITE D'AIX-MARSEILLE (FR) | 2017-06-22 | — | — | WO | disclosed |