Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.32 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15872033 | 0.84 | SMN1; SMN2 (0.46) | HTTSMN1; SMN2CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL18757121 | 0.84 | HCAR3 (0.36) | HTTSMN1; SMN2ALDH1A1TDP1TAAR1 | |
| SCHEMBL11054233 | 0.82 | MAPT (0.38) | HTTSMN1; SMN2ALDH1A1TDP1TAAR1 | |
| SCHEMBL23469288 | 0.79 | ALDH1A1 (0.38) | HTTSMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL10111220 | 0.79 | ALDH1A1 (0.38) | HTTSMN1; SMN2CYP1A2ALDH1A1TDP1 | |
| SCHEMBL17127897 | 0.78 | ALDH1A1 (0.47) | HTTSMN1; SMN2CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL22607366 | 0.78 | LMNA (0.44) | HTTSMN1; SMN2ALDH1A1UTS2RLMNA | |
| SCHEMBL7997975 | 0.78 | ALDH1A1 (0.40) | HTTSMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL763820 | 0.75 | AR (0.41) | SMN1; SMN2CYP2D6CYP2C19ALDH1A1TAAR1 | |
| SCHEMBL10104423 | 0.74 | CRHR1 (0.37) | HTTSMN1; SMN2CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170174689-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174689-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL3 | HTT 1155/4885SMN1; SMN2 2394/4885CYP1A2 3383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.