Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30011 | 0.81 | MAPT (0.54) | TDP1ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL29904251 | 0.81 | MAPT (0.54) | TDP1ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL1225953 | 0.77 | PGR (0.51) | TSHRMAPTMEN1KMT2ALMNA | |
| SCHEMBL13306916 | 0.77 | GRIA1 (0.53) | TDP1ALDH1A1TSHRNPBWR1MAPT | |
| Indole SCHEMBL23362403 | 0.75 | NPBWR1 (0.42) | TDP1ALDH1A1TSHRNPBWR1MAPT | |
| Indole SCHEMBL710464 | 0.74 | TRPA1 (0.55) | TDP1ALDH1A1NPBWR1MAPTMEN1 | |
| SCHEMBL15477943 | 0.73 | ALDH1A1 (0.51) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL5659592 | 0.73 | TRPA1 (0.50) | MEN1KMT2ANR3C1PGRNPC1 | |
| SCHEMBL29935827 | 0.73 | MEN1 (0.46) | TDP1ALDH1A1TSHRMAPTMEN1 | |
| SCHEMBL22076862 | 0.73 | MEN1 (0.46) | TDP1ALDH1A1TSHRMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107753486-B | Low drug resistance and low side effect therapeutic agent for chronic myelogenous leukemia containing 1, 6-disubstituted indole compound | 韩国科学技术研究院 | 2021-03-30 | — | — | CN | disclosed |
| US-10130631-B2 | CML therapeutic agents with reduced drug-resistance and side-effect comprising 1,6-disubstituted indole compounds | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-11-20 | — | — | US | disclosed |
| CN-107753486-A | Low resistance to the action of a drug low side effect chronic myelogenous leukemia therapeutic agent containing 1,6 disubstituted indole compounds | 韩国科学技术研究院 | 2018-03-06 | — | — | CN | disclosed |
| US-20180050036-A1 | CML THERAPEUTIC AGENTS WITH REDUCED DRUG-RESISTANCE AND SIDE-EFFECT COMPRISING 1,6-DISUBSTITUTED INDOLE COMPOUNDS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-02-22 | — | — | US | disclosed |
| US-8765749-B2 | 1,6-disubstituted indole compounds as protein kinase inhibitors | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-07-01 | — | — | US | disclosed |
| US-8765749-B2 | 1,6-disubstituted indole compounds as protein kinase inhibitors | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-07-01 | — | — | US | disclosed |
| US-20120271048-A1 | NOVEL 1,6-DISUBSTITUTED INDOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-10-25 | — | — | US | disclosed |
| US-20120271048-A1 | NOVEL 1,6-DISUBSTITUTED INDOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-10-25 | — | — | US | disclosed |
| WO-2011052923-A2 | NOVEL 1,6-DISUBSTITUTED INDOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-05-05 | — | — | WO | disclosed |
| WO-2011052923-A2 | NOVEL 1,6-DISUBSTITUTED INDOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120271048-A1 | NOVEL 1,6-DISUBSTITUTED INDOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | MAP3K6, MAP3K20, MAP3K1 | TDP1 1815/4885ALDH1A1 3172/4885TSHR 2710/4885 |
| US-10130631-B2 | CML therapeutic agents with reduced drug-resistance and side-effect comprising 1,6-disubstituted indole compounds | ABL1, MCL1, INMT | TDP1 2114/4885ALDH1A1 202/4885TSHR 3613/4885 |
| US-20180050036-A1 | CML THERAPEUTIC AGENTS WITH REDUCED DRUG-RESISTANCE AND SIDE-EFFECT COMPRISING 1,6-DISUBSTITUTED INDOLE COMPOUNDS | ABL1, MCL1, INMT | TDP1 2114/4885ALDH1A1 202/4885TSHR 3613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.