Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR1A | P36894 | 13/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 13/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 13/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 12/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16435034 | 0.89 | CYP11B1 (0.40) | GRIN1GRIN2BAKR1C3AKR1C2PDE5A | |
| SCHEMBL1898876 | 0.89 | BMPR1A (0.40) | BMPR1AACVRL1ACVR1BMPR1BTGFBR1 | |
| SCHEMBL2003570 | 0.81 | P2RX3 (0.42) | PDE5A | |
| SCHEMBL1896090 | 0.79 | RXRA (0.40) | BMPR1AACVRL1ACVR1BMPR1BTGFBR1 | |
| SCHEMBL16435091 | 0.74 | HRH3 (0.41) | AKR1C3AKR1C2HRH3 | |
| SCHEMBL12472190 | 0.72 | LMNA (0.40) | — | |
| SCHEMBL662686 | 0.72 | LMNA (0.40) | — | |
| SCHEMBL9108805 | 0.69 | P2RX3 (0.43) | — | |
| SCHEMBL3369814 | 0.69 | DPP8 (0.40) | BMPR1AACVRL1ACVR1BMPR1BTGFBR1 | |
| SCHEMBL9108017 | 0.68 | PDE5A (0.49) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056985-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2011-05-12 | — | — | WO | disclosed |