Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 6/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 6/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 5/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.35 |
| ▸ | DHODH | Q02127 | 3/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1898876 | 0.80 | BMPR1A (0.40) | BMPR1AACVRL1ACVR1BMPR1BTGFBR1 | |
| SCHEMBL1902303 | 0.79 | BMPR1A (0.39) | BMPR1AACVRL1ACVR1BMPR1BTGFBR1 | |
| SCHEMBL2003570 | 0.73 | P2RX3 (0.42) | HDAC1 | |
| SCHEMBL28853764 | 0.66 | RXRA (0.73) | RXRARXRBNR4A2HDAC1HDAC2 | |
| SCHEMBL9103481 | 0.65 | NOTUM (0.40) | PTGS2AKR1C3AKR1C2 | |
| SCHEMBL16435091 | 0.65 | HRH3 (0.41) | AKR1C3AKR1C2 | |
| SCHEMBL7467666 | 0.64 | LTA4H (0.51) | RXRARXRBFFAR1FFAR4NR4A2 | |
| SCHEMBL12472190 | 0.64 | LMNA (0.40) | HDAC1 | |
| SCHEMBL662686 | 0.64 | LMNA (0.40) | HDAC1 | |
| SCHEMBL3369814 | 0.64 | DPP8 (0.40) | BMPR1AACVRL1ACVR1BMPR1BTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056985-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2011-05-12 | — | — | WO | disclosed |