Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | PARL | Q9H300 | 1/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1864018 | 0.84 | PLCG1 (0.38) | FFAR2MAPK1CA2CA9ALDH1A1 | |
| SCHEMBL2304680 | 0.84 | STAT3 (0.38) | MAPK1CA2CA9ALDH1A1GAA | |
| SCHEMBL6556991 | 0.77 | GBA1 (0.43) | FFAR2MAPK1PARLGBA1ENPP3 | |
| SCHEMBL28184784 | 0.76 | ALDH1A1 (0.44) | FFAR2MAPK1PARLGBA1ENPP3 | |
| SCHEMBL18372671 | 0.73 | CYP2D6 (0.37) | MAPK1ENPP3ENPP1ENPP2ALDH1A1 | |
| SCHEMBL23159147 | 0.71 | FFAR2 (0.47) | FFAR2MAPK1PARLGBA1PRMT5 | |
| SCHEMBL6555814 | 0.71 | SMN1; SMN2 (0.41) | MAPK1PARLGBA1ALDH1A1GAA | |
| SCHEMBL13922018 | 0.71 | ALDH1A1 (0.58) | ALDH1A1GAAKDM4EHPGDKMT2A | |
| SCHEMBL2796319 | 0.71 | ARNT (0.39) | ALDH1A1KDM4E | |
| SCHEMBL9844160 | 0.70 | PRMT5 (0.60) | MAPK1PARLTDP1PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107848953-B | Fused ring gamma-amino acid derivative, preparation method and application thereof in medicine | 四川海思科制药有限公司 | 2021-05-18 | — | — | CN | disclosed |
| CN-107848953-A | Fused rings γ amino acid derivativges and preparation method thereof and application in medicine | 四川海思科制药有限公司 | 2018-03-27 | — | — | CN | disclosed |
| WO-2017107907-A1 | CONDENSED RING Γ-AMINO ACID DERIVATIVE AND PREPARATION METHOD AND MEDICAL USE THEREOF | 四川海思科制药有限公司 | 2017-06-29 | — | — | WO | disclosed |
| WO-2017107907-A1 | CONDENSED RING Γ-AMINO ACID DERIVATIVE AND PREPARATION METHOD AND MEDICAL USE THEREOF | 四川海思科制药有限公司 | 2017-06-29 | — | — | WO | disclosed |