Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.73 |
| ▸ | HPGD | P15428 | 6/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19066919 | 0.87 | PHGDH (0.77) | PHGDHALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL19066922 | 0.86 | PHGDH (0.76) | PHGDHALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL8288738 | 0.76 | HPGD (0.74) | PHGDHALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL10143934 | 0.71 | ALDH1A1 (0.98) | PHGDHALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL5449432 | 0.67 | ALDH1A1 (1.00) | ALDH1A1HPGDMAPK1KDM4ETSHR | |
| SCHEMBL11099034 | 0.67 | ALDH1A1 (0.56) | PHGDHALDH1A1HPGDKDM4ETSHR | |
| SCHEMBL15503673 | 0.67 | KMT2A (1.00) | ALDH1A1HPGDMAPK1KDM4ETSHR | |
| SCHEMBL859237 | 0.67 | NPC1 (0.61) | ALDH1A1HPGDKDM4ETSHRRAB9A | |
| SCHEMBL4140119 | 0.66 | ALDH1A1 (0.62) | PHGDHALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL5456095 | 0.65 | ALDH1A1 (0.77) | ALDH1A1HPGDMAPK1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119355267-A | Application of NOX4 and tumor-associated neutrophils in prediction of gastric cancer immune curative effect | 上海交通大学医学院附属瑞金医院 | 2025-01-24 | — | — | CN | claimed |
| CN-119326889-A | PHGDH inhibitor and application thereof in treatment of disseminated tumor cells | 复旦大学附属中山医院 | 2025-01-21 | — | — | CN | claimed |
| CN-118436641-A | Application of compound CBR-5884 in preparation of ovarian cancer stem cell proliferation inhibitor | 广州医科大学附属妇女儿童医疗中心 | 2024-08-06 | — | — | CN | claimed |
| CN-116350789-A | Antitumor application of composition based on PHGDH activity inhibition | 中国医学科学院药物研究所 | 2023-06-30 | — | — | CN | claimed |
| US-12628858-B2 | Therapy for colorectal and small intestine cancers | CORNELL UNIVERSITY (US) | 2026-05-19 | — | — | US | disclosed |
| US-12565654-B2 | Extracellular vesicle secretion reducing agent for reducing extracellular vesicle secretion, and use of the same | THEORIA SCIENCE INC. (JP) | 2026-03-03 | — | — | US | disclosed |
| CN-119345334-B | Application of macrophage PHGDH in preparation of TAK1 inhibitor | 四川省医学科学院·四川省人民医院 | 2025-03-18 | — | — | CN | disclosed |
| CN-119564668-A | Application of compound in preparation of PHGDH active site inhibitor | 首都医科大学附属北京中医医院 | 2025-03-07 | — | — | CN | disclosed |
| CN-115466229-B | Para-amidobenzenesulfonyl compound and application thereof | 上海中医药大学 | 2025-01-24 | — | — | CN | disclosed |
| CN-119355267-A | Application of NOX4 and tumor-associated neutrophils in prediction of gastric cancer immune curative effect | 上海交通大学医学院附属瑞金医院 | 2025-01-24 | — | — | CN | disclosed |
| CN-119345334-A | Application of macrophage PHGDH in preparation of TAK1 inhibitor | 四川省医学科学院·四川省人民医院 | 2025-01-24 | — | — | CN | disclosed |
| CN-119326889-A | PHGDH inhibitor and application thereof in treatment of disseminated tumor cells | 复旦大学附属中山医院 | 2025-01-21 | — | — | CN | disclosed |
| CN-115466229-A | P-acylamino benzenesulfonyl compound and application thereof | 上海中医药大学 | 2022-12-13 | — | — | CN | disclosed |
| CN-110392681-B | Tosylacetate-based compounds and derivatives thereof as PHGDH inhibitors | 勃林格殷格翰国际有限公司 | 2022-11-25 | — | — | CN | disclosed |
| CN-115181728-A | Application of substance for inhibiting serine metabolism in regulating macrophage polarization by regulating IGF1-p38 axis | 天津医科大学 | 2022-10-14 | — | — | CN | disclosed |
| CN-115181728-A | Application of substance for inhibiting serine metabolism in regulating macrophage polarization by regulating IGF1-p38 axis | 天津医科大学 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022120195-A1 | METHOD OF TREATING AND PREVENTING VIRAL INFECTION | THE GENERAL HOSPITAL CORPORATION (US) | 2022-06-09 | — | — | WO | disclosed |
| US-11304929-B2 | Tosylacetate based compounds and derivatives thereof as PHGDH inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-04-19 | — | — | US | disclosed |
| US-20190010144-A1 | SMALL MOLECULE INHIBITOR OF 3-PHOSPHOGLYCERATE DEHYDROGENASE AND USES THEREOF | CORNELL UNIVERSITY | 2019-01-10 | — | — | US | disclosed |
| WO-2017117532-A1 | SMALL MOLECULE INHIBITOR OF 3-PHOSPHOGLYCERATE DEHYDROGENASE AND USES THEREOF | CANTLEY LEWIS C (US) | 2017-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11304929-B2 | Tosylacetate based compounds and derivatives thereof as PHGDH inhibitors | PHGDH, G6PD, PHPT1 | PHGDH 1/4885ALDH1A1 168/4885HPGD 63/4885 |
| US-20190010144-A1 | SMALL MOLECULE INHIBITOR OF 3-PHOSPHOGLYCERATE DEHYDROGENASE AND USES THEREOF | PHGDH, G6PD, PGD | PHGDH 1/4885ALDH1A1 211/4885HPGD 17/4885 |
| US-12628858-B2 | Therapy for colorectal and small intestine cancers | FABP2, PKN2, APC | PHGDH 203/4885ALDH1A1 4014/4885HPGD 4514/4885 |
| US-12565654-B2 | Extracellular vesicle secretion reducing agent for reducing extracellular vesicle secretion, and use of the same | EXOSC5, EXOSC4, EXOSC9 | PHGDH 1426/4885ALDH1A1 2814/4885HPGD 3713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.