Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | PGR | P06401 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SHBG | P04278 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017258 | 0.76 | CYP19A1 (0.60) | LMNACYP3A4ALDH1A1TSHRSHBG | |
| SCHEMBL24476668 | 0.76 | CYP3A4 (0.66) | LMNACYP3A4PGRCYP2C19ABCB11 | |
| SCHEMBL3652905 | 0.75 | CYP19A1 (0.53) | ALDH1A1SHBGCYP19A1 | |
| SCHEMBL14962034 | 0.74 | LMNA (0.67) | LMNACYP3A4PGRCYP2C19ABCB11 | |
| SCHEMBL13259847 | 0.74 | LMNA (0.67) | LMNACYP3A4PGRCYP2C19ABCB11 | |
| SCHEMBL19073469 | 0.74 | LMNA (0.67) | LMNACYP3A4PGRCYP2C19ABCB11 | |
| SCHEMBL11801563 | 0.71 | CYP19A1 (0.64) | LMNACYP3A4PGRCYP2C19ABCB11 | |
| SCHEMBL6437488 | 0.71 | SHBG (0.62) | LMNACYP3A4PGRESR1NR3C1 | |
| SCHEMBL30944712 | 0.68 | CYP19A1 (0.32) | ALDH1A1SHBGCYP19A1 | |
| SCHEMBL11650163 | 0.67 | LMNA (0.70) | LMNACYP3A4PGRCYP2C19ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2977084-B1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF FLUID ACCUMULATION IN AND/ OR UNDER THE RETINA | INSERM (INSTITUT NAT DE LA SANTÉ ET DE LA RECH MÉDICALE) (FR) | 2017-07-05 | — | — | EP | disclosed |