SCHEMBL19085976 — predicted protein targets

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	DDR2	Q16832	1/20	0.46

▸	ENPP2	Q13822	1/20	0.41

▸	PRMT5	O14744	3/20	0.41

▸	WDR77	Q9BQA1	3/20	0.41

▸	ROCK2	O75116	6/20	0.39

▸	ROCK1	Q13464	1/20	0.39

▸	MAOB	P27338	1/20	0.38

▸	CHRM3	P20309	1/20	0.37

▸	CYP3A4	P08684	1/20	0.36

▸	CYP2C9	P11712	1/20	0.36

▸	CYP2C19	P33261	1/20	0.36

▸	NAMPT	P43490	1/20	0.36

▸	ADORA1	P30542	1/20	0.36

▸	METTL3	Q86U44	1/20	0.36

▸	HRH4	Q9H3N8	1/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19086254	0.92	PRMT5 (0.40)	DDR2ENPP2PRMT5WDR77MAOB
SCHEMBL19085994	0.91	ROCK2 (0.41)	PRMT5WDR77ROCK2ROCK1MAOB
SCHEMBL19085995	0.91	METTL3 (0.41)	PRMT5WDR77ROCK2ROCK1MAOB
SCHEMBL19085984	0.91	ROCK2 (0.42)	PRMT5WDR77ROCK2ROCK1MAOB
SCHEMBL19085996	0.89	ROCK2 (0.53)	PRMT5WDR77ROCK2ROCK1NAMPT
SCHEMBL19086042	0.89	PRMT5 (0.38)	ENPP2PRMT5WDR77MAOBMETTL3
SCHEMBL19086002	0.88	PRMT5 (0.38)	ENPP2PRMT5WDR77ROCK2ROCK1
SCHEMBL19085991	0.87	MAOB (0.42)	PRMT5WDR77ROCK2ROCK1MAOB
SCHEMBL19086985	0.87	PRMT5 (0.41)	PRMT5WDR77ROCK2ROCK1MAOB
SCHEMBL19086994	0.87	MAOB (0.39)	PRMT5WDR77ROCK2ROCK1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017114275-A1	COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME	成都先导药物开发有限公司	2017-07-06	—	—	WO	disclosed