Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 9/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.40 |
| ▸ | KDM1A | O60341 | 4/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19087008 | 0.82 | PRMT5 (0.41) | ALDH1A1KDM4EPRMT5WDR77USP2 | |
| SCHEMBL19086228 | 0.81 | HDAC6 (0.46) | ALDH1A1KDM4ELMNAPRMT5WDR77 | |
| SCHEMBL19086320 | 0.79 | KDM4E (0.56) | ALDH1A1KDM4ELMNAPRMT5WDR77 | |
| SCHEMBL19086033 | 0.78 | ALDH1A1 (0.51) | ALDH1A1KDM4ELMNAUSP2SMN1; SMN2 | |
| SCHEMBL19087009 | 0.77 | ALDH1A1 (0.49) | ALDH1A1KDM4ELMNAPRMT5WDR77 | |
| SCHEMBL19086231 | 0.75 | ALDH1A1 (0.56) | ALDH1A1KDM4EPRMT5WDR77MEN1 | |
| SCHEMBL19086261 | 0.73 | PRMT5 (0.41) | ALDH1A1KDM4EPRMT5WDR77HDAC6 | |
| SCHEMBL19086223 | 0.73 | METTL3 (0.43) | ALDH1A1KDM4EPRMT5WDR77HDAC6 | |
| SCHEMBL19086350 | 0.71 | MAPT (0.48) | ALDH1A1KDM4ELMNAPRMT5WDR77 | |
| SCHEMBL19086010 | 0.71 | PRMT5 (0.36) | ALDH1A1KDM4ELMNAPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114275-A1 | COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME | 成都先导药物开发有限公司 | 2017-07-06 | — | — | WO | disclosed |