SCHEMBL19086145

SCHEMBL19086145

CC[C@@H](NC(=O)c1ccc2[nH]ncc2c1)C(=O)N1CCc2sc(C(=O)Nc3cccc4c3CCC4)cc2C1

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 4/20 0.36
ROCK1 Q13464 3/20 0.36
LCK P06239 1/20 0.36
KDR P35968 1/20 0.36
JAK3 P52333 1/20 0.36
MAPK14 Q16539 1/20 0.36
PRMT5 O14744 6/20 0.36
WDR77 Q9BQA1 6/20 0.36
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 2/20 0.35
MAPT P10636 2/20 0.35
HPGD P15428 1/20 0.35
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CCKBR P32239 1/20 0.35
DDR1 Q08345 1/20 0.35
BTK Q06187 2/20 0.35
MAPK1 P28482 1/20 0.34
TRPV1 Q8NER1 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19085993 0.90 BTK (0.38) ROCK2ROCK1PRMT5WDR77ALDH1A1
SCHEMBL19086144 0.90 ROCK2 (0.35) ROCK2ROCK1PRMT5WDR77KDM4E
SCHEMBL19085987 0.88 KDM1A (0.41) ROCK2ROCK1PRMT5WDR77ALDH1A1
SCHEMBL19086146 0.88 ROCK2 (0.35) ROCK2ROCK1PRMT5WDR77DDR1
SCHEMBL19085981 0.87 TRPV1 (0.41) ROCK2ROCK1PRMT5WDR77DDR1
SCHEMBL19085999 0.87 TRPV1 (0.41) ROCK2ROCK1PRMT5WDR77DDR1
SCHEMBL19086004 0.86 PRMT5 (0.39) ROCK2ROCK1PRMT5WDR77
SCHEMBL19085989 0.85 MAOB (0.41) ROCK2ROCK1
SCHEMBL19085978 0.85 ROCK2 (0.46) ROCK2ROCK1PRMT5WDR77TRPV1
SCHEMBL19086160 0.84 HDAC6 (0.38) ROCK2ROCK1PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017114275-A1 COMPOUND FOR INHIBITING ROCK, PREPARATION METHOD AND USE OF SAME 成都先导药物开发有限公司 2017-07-06 WO disclosed