Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 6/20 | 0.34 |
| ▸ | PPARG | P37231 | 3/20 | 0.33 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17721709 | 0.90 | REN (0.37) | ALDH1A1LMNAPNMTPOLBMEN1 | |
| SCHEMBL19087147 | 0.87 | SIGMAR1 (0.45) | POLBRENSIGMAR1KDM4E | |
| SCHEMBL19087209 | 0.81 | KDM4E (0.35) | ALDH1A1LMNAMAPTMAPK1REN | |
| SCHEMBL29840524 | 0.80 | REN (0.39) | ALDH1A1LMNAPNMTPOLBMEN1 | |
| SCHEMBL16930095 | 0.80 | REN (0.39) | ALDH1A1LMNAPNMTPOLBMEN1 | |
| SCHEMBL17709266 | 0.77 | REN (0.48) | RENSIGMAR1 | |
| SCHEMBL19087208 | 0.76 | REN (0.36) | ALDH1A1LMNAPOLBMEN1USP2 | |
| SCHEMBL17732271 | 0.76 | REN (0.40) | ALDH1A1RENPPARGPPARDPPARA | |
| SCHEMBL17266006 | 0.74 | FOS (0.46) | ALDH1A1LMNAPOLBMEN1USP2 | |
| SCHEMBL19087185 | 0.73 | REN (0.42) | ALDH1A1RENSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114812-A1 | COMBINATION THERAPY OF AN HBSAG INHIBITOR AND AN INTERFERON | F. HOFFMANN-LA ROCHE AG (CH) | 2017-07-06 | — | — | WO | disclosed |