Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | HCK | P08631 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.52 |
| ▸ | PRKDC | P78527 | 1/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28014706 | 0.82 | RXRA (0.66) | MRGPRX4MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL14228414 | 0.82 | MAPT (0.56) | MRGPRX4MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL12303132 | 0.81 | KDM4E (0.60) | MAPTTDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL12667384 | 0.81 | MRGPRX4 (0.60) | MRGPRX4MCL1MAPTMAPK1TDP1 | |
| SCHEMBL25081934 | 0.81 | MAPT (0.64) | MRGPRX4MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL2912541 | 0.81 | MAPT (0.55) | MCL1MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL19286354 | 0.81 | ALOX5 (0.58) | MAPTMAPK1TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL5889698 | 0.80 | CDK4 (0.60) | MRGPRX4MCL1MAPTMAPK1TDP1 | |
| SCHEMBL5889696 | 0.80 | CDK4 (0.60) | MRGPRX4MCL1MAPTMAPK1TDP1 | |
| SCHEMBL19078684 | 0.80 | RXRA (0.49) | MRGPRX4MCL1MAPTMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170190669-A1 | PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | H. LUNDBECK A/S (DK) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190669-A1 | PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ABHD6, FAAH, FAAH2 | MRGPRX4 256/4885MCL1 523/4885MAPT 4504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.