Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.80 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.80 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.80 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.80 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.80 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.80 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.80 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.80 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.80 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.80 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.80 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.77 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.77 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.69 |
| ▸ | MMP13 | P45452 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | CA1 | P00915 | 2/20 | 0.66 |
| ▸ | CA2 | P00918 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27903146 | 0.90 | HDAC6 (0.75) | HDAC6HDAC1HDAC2HDAC8HDAC3 | |
| SCHEMBL8042301 | 0.90 | HDAC6 (0.77) | HDAC6HDAC1HDAC2HDAC8HDAC3 | |
| SCHEMBL6386658 | 0.89 | HDAC6 (1.00) | HDAC6HDAC1HDAC2HDAC8HDAC3 | |
| SCHEMBL539059 | 0.89 | EPHX2 (0.84) | HDAC6HDAC1HDAC2HDAC8HDAC3 | |
| SCHEMBL8163396 | 0.85 | HSP90AA1 (0.68) | HDAC6HDAC1HDAC2HDAC8HDAC3 | |
| SCHEMBL1927145 | 0.84 | EPHX2 (0.77) | HDAC6HDAC1HDAC2HDAC8HDAC3 | |
| SCHEMBL4981515 | 0.84 | EPHX2 (0.77) | HDAC6HDAC1HDAC2HDAC8HDAC3 | |
| SCHEMBL1926318 | 0.84 | EPHX2 (0.77) | HDAC6HDAC1HDAC2HDAC8HDAC3 | |
| SCHEMBL3025457 | 0.84 | HDAC6 (0.91) | HDAC6HDAC1HDAC2HDAC8HDAC3 | |
| SCHEMBL16495652 | 0.82 | HPGDS (0.82) | HDAC6HDAC1HDAC2HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181235-B2 | Substituted pyridines for modulating the WNT signaling pathway | NOVARTIS AG (CH) | 2015-11-10 | — | — | US | disclosed |
| US-9181235-B2 | Substituted pyridines for modulating the WNT signaling pathway | NOVARTIS AG (CH) | 2015-11-10 | — | — | US | disclosed |
| EP-2588453-B1 | COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY | NOVARTIS AG (CH) | 2015-04-01 | — | — | EP | disclosed |
| US-20130079328-A1 | COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY | NOVARTIS AG (CH) | 2013-03-28 | — | — | US | disclosed |
| US-20130079328-A1 | COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY | NOVARTIS AG (CH) | 2013-03-28 | — | — | US | disclosed |
| WO-2012003189-A1 | COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY | IRM LLC (BM) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130079328-A1 | COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY | WNT3A, WNT1, WNT3 | HDAC6 1783/4885HDAC1 830/4885HDAC2 1820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.