Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23630645 | 0.83 | NAMPT (0.60) | NAMPTHDAC4HDAC1HDAC2MAP4K4 | |
| SCHEMBL19908021 | 0.81 | HDAC3 (0.46) | NAMPTHDAC4HDAC1HDAC2MAPT | |
| SCHEMBL19145574 | 0.79 | DRD1 (0.40) | NAMPTHDAC4MAPTKDM1AMAOB | |
| SCHEMBL12352674 | 0.79 | ALDH1A1 (0.40) | HDAC4HDAC1HDAC2MAPTHDAC3 | |
| SCHEMBL22326357 | 0.72 | SIGMAR1 (0.50) | — | |
| SCHEMBL12093537 | 0.70 | MMP13 (0.61) | NAMPTHDAC4HDAC1HDAC2HDAC3 | |
| SCHEMBL12090016 | 0.69 | NAMPT (0.58) | NAMPTHDAC4HDAC1HDAC2HDAC3 | |
| SCHEMBL2660481 | 0.69 | NCF1 (0.42) | NAMPTHDAC4HDAC1HDAC2MAPT | |
| SCHEMBL16616770 | 0.69 | NAMPT (0.67) | NAMPTHDAC4EGLN1 | |
| SCHEMBL4040585 | 0.68 | LMNA (0.53) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017121444-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-07-20 | — | — | WO | disclosed |