Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728484 | 0.85 | ALDH1A1 (0.51) | ALDH1A1KMT2AKDM4EALOX12HPGD | |
| SCHEMBL9728781 | 0.79 | ALDH1A1 (0.54) | ALDH1A1KMT2AKDM4EALOX12MEN1 | |
| SCHEMBL9409114 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KMT2AKDM4EHPGDMEN1 | |
| SCHEMBL9728508 | 0.76 | KMT2A (0.47) | ALDH1A1KMT2AKDM4EALOX12HPGD | |
| SCHEMBL28409026 | 0.75 | KMT2A (0.61) | ALDH1A1KMT2AKDM4EHPGDMAPT | |
| SCHEMBL10400661 | 0.74 | PKM (0.66) | ALDH1A1KMT2AKDM4EHPGDMEN1 | |
| SCHEMBL9818479 | 0.74 | POLB (0.52) | ALDH1A1KMT2AKDM4EALOX12HPGD | |
| SCHEMBL4444645 | 0.72 | KMT2A (0.67) | ALDH1A1KMT2AKDM4EHPGDMAPT | |
| SCHEMBL29408467 | 0.72 | KMT2A (0.67) | ALDH1A1KMT2AKDM4EHPGDMAPT | |
| SCHEMBL43644 | 0.72 | KMT2A (0.67) | ALDH1A1KMT2AKDM4EHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981920-B2 | Inhibitors of histone deacetylase | RODIN THERAPEUTICS, INC. (US) | 2018-05-29 | — | — | US | disclosed |
| US-20170204070-A1 | INHIBITORS OF HISTONE DEACETYLASE | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2017-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170204070-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC2, HDAC1, HDAC5 | ALDH1A1 619/4885KMT2A 18/4885KDM4E 258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.