Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
| ▸ | GOT1 | P17174 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24762611 | 0.76 | PABPC1 (0.33) | AXLPRKCICCR8GOT1 | |
| SCHEMBL25667793 | 0.75 | BTK (0.46) | GOT1 | |
| SCHEMBL806532 | 0.72 | CFB (0.40) | AXLPRKCICCR8GOT1 | |
| SCHEMBL24762761 | 0.70 | MAPT (0.46) | GOT1 | |
| SCHEMBL25032367 | 0.70 | CA12 (0.32) | — | |
| SCHEMBL24872829 | 0.67 | OPRK1 (0.39) | AXLPRKCICCR8 | |
| SCHEMBL27580004 | 0.67 | TDP2 (0.32) | — | |
| SCHEMBL20350309 | 0.67 | ALDH1A1 (0.36) | CCR8 | |
| SCHEMBL2983820 | 0.66 | ALDH1A1 (0.38) | AXLPRKCICCR8 | |
| SCHEMBL806287 | 0.66 | TNF (0.39) | AXLPRKCICCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509600-B1 | THERAPEUTICALLY ACTIVE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CHARACTERIZED AS HAVING AN IDH MUTATION | AGIOS PHARMACEUTICALS INC (US) | 2017-08-02 | — | — | EP | disclosed |