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Sugi Predict / Compounds / 2-Aminopurine

2-Aminopurine

2-Aminopurine

SCHEMBL1919609

Nc1ncc2[nH]cnc2n1.OC[C@H]1OC(O)C[C@@H]1O

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.55
▸ RXFP1 Q9HBX9 2/20 0.49
▸ DNMT1 P26358 2/20 0.42
▸ ADRB1 P08588 1/20 0.42
▸ KDM4E B2RXH2 1/20 0.35
▸ LMNA P02545 3/20 0.34
▸ TP53 P04637 2/20 0.34
▸ HTT P42858 2/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.34
▸ PNP P00491 1/20 0.34
▸ PDE4D Q08499 1/20 0.34
▸ PDE3A Q14432 1/20 0.34
▸ PAK1 Q13153 1/20 0.34
▸ GMNN O75496 1/20 0.32
▸ NFKB1 P19838 1/20 0.32
▸ THPO P40225 1/20 0.32
▸ MTOR P42345 1/20 0.32
▸ RAB9A P51151 1/20 0.32
▸ BLM P54132 1/20 0.32
▸ HBB P68871 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Aminopurine SCHEMBL28775710 0.81 ALDH1A1 (0.59) ALDH1A1RXFP1DNMT1KDM4ELMNA
2,6-Diaminopurine SCHEMBL7801065 0.81 PDPK1 (0.55) RXFP1DNMT1ADRB1LMNATP53
2-Aminopurine SCHEMBL1507729 0.81 ALDH1A1 (0.55) ALDH1A1RXFP1DNMT1ADRB1KDM4E
2-Aminopurine SCHEMBL4342854 0.74 ALDH1A1 (0.79) ALDH1A1RXFP1KDM4EPAK1CDK2
2-Aminopurine SCHEMBL19521137 0.74 ALDH1A1 (0.49) ALDH1A1RXFP1KDM4ECDK2CDK1
2-Aminopurine SCHEMBL5634 0.74 ALDH1A1 (1.00) ALDH1A1RXFP1KDM4ELMNAPAK1
2-Aminopurine SCHEMBL31379734 0.72 ALDH1A1 (0.96) ALDH1A1RXFP1KDM4ELMNAPAK1
2-Aminopurine SCHEMBL3144589 0.72 ALDH1A1 (0.96) ALDH1A1RXFP1KDM4ELMNAPAK1
2-Aminopurine SCHEMBL29056388 0.72 ALDH1A1 (0.96) ALDH1A1RXFP1KDM4ELMNAPAK1
2-Aminopurine SCHEMBL357699 0.72 ALDH1A1 (0.96) ALDH1A1RXFP1KDM4EPAK1BLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105916873-B Efficient synthesis of long RNAs using the reverse method 坎姆根公司 2020-06-19 — — CN disclosed
EP-3060572-A1 DITHIOLANE FUNCTIONALIZED NUCLEOSIDE AMIDITES AND SUPPORTS FOR STRONGER IMMOBILIZATION OF BIO-MOLECULES ON SOLID SURFACES Chemgenes Corporation (US) 2016-08-31 — — EP disclosed
WO-2015061507-A1 DITHIOLANE FUNCTIONALIZED NUCLEOSIDE AMIDITES AND SUPPORTS FOR STRONGER IMMOBILIZATION OF BIO-MOLECULES ON SOLID SURFACES CHEMGENES CORPORATION (US) 2015-04-30 — — WO disclosed
EP-2326656-A2 RNA SYNTHESIS - PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION, AND APPLICATION IN CONVENIENT INTRODUCTION OF LIGANDS, CHROMOPHORES AND MODIFICATIONS OF SYNTHETIC RNA AT THE 3' - END Chemgenes Corporation (US) 2011-06-01 — — EP disclosed
WO-2010062404-A2 N-FMOC NUCLEOSIDES AND PHOSPHORAMIDITES, AND OLIGONUCLEOTIDE SYNTHESIS CHEMGENES CORPORATION (US) 2010-06-03 — — WO disclosed
WO-2010027512-A9 RNA SYNTHESIS - PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION, AND APPLICATION IN CONVENIENT INTRODUCTION OF LIGANDS, CHROMOPHORES AND MODIFICATIONS OF SYNTHETIC RNA AT THE 3' - END CHEMGENES CORPORATION (US) 2010-04-22 — — WO disclosed
WO-2010027512-A2 RNA SYNTHESIS - PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION, AND APPLICATION IN CONVENIENT INTRODUCTION OF LIGANDS, CHROMOPHORES AND MODIFICATIONS OF SYNTHETIC RNA AT THE 3' - END CHEMGENES CORPORATION (US) 2010-03-11 — — WO disclosed