Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20000789 | 0.86 | ALDH1A1 (0.40) | ALDH1A1MAPK1LMNASMN1; SMN2HTR1D | |
| SCHEMBL19204117 | 0.84 | ALDH1A1 (0.44) | ALDH1A1MAPK1LMNASMN1; SMN2HTR1D | |
| SCHEMBL24627773 | 0.81 | HTR1D (0.43) | ALDH1A1MAPK1LMNASMN1; SMN2HTR1D | |
| SCHEMBL21523926 | 0.76 | ATM (0.42) | ALDH1A1MAPK1LMNASMN1; SMN2HTR1D | |
| SCHEMBL21449928 | 0.74 | CYP2D6 (0.41) | ALDH1A1MAPK1LMNASMN1; SMN2HTR1D | |
| SCHEMBL20207510 | 0.73 | CYP2D6 (0.40) | ALDH1A1MAPK1LMNASMN1; SMN2HTR1D | |
| SCHEMBL5165521 | 0.73 | CYP2D6 (0.61) | ALDH1A1SMN1; SMN2CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL27012358 | 0.73 | CYP2D6 (0.40) | ALDH1A1MAPK1LMNASMN1; SMN2HTR1D | |
| SCHEMBL21849299 | 0.72 | HTR1D (0.42) | ALDH1A1MAPK1LMNASMN1; SMN2HTR1D | |
| SCHEMBL19779066 | 0.72 | HTR1D (0.36) | ALDH1A1LMNAHTR1DMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230038823-A1 | CAPSID INHIBITORS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. (US) | 2023-02-09 | — | — | US | disclosed |
| US-11541046-B2 | Spirolactone compounds | QUIXGEN, INC. (US) | 2023-01-03 | — | — | US | disclosed |
| US-20210145822-A1 | Novel Spirolactone Compounds | QUIXGEN, INC. (US) | 2021-05-20 | — | — | US | disclosed |
| US-9969689-B2 | Aryl ethers and uses thereof | PELOTON THERAPEUTICS, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170217891-A1 | ARYL ETHERS AND USES THEREOF | PELOTON THERAPEUTICS, INC. | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11541046-B2 | Spirolactone compounds | ACACA, AKR1C2, AKR1A1 | ALDH1A1 40/4885MAPK1 141/4885LMNA 3974/4885 |
| US-20230038823-A1 | CAPSID INHIBITORS FOR THE TREATMENT OF HIV | HAVCR2, MAVS, CD4 | ALDH1A1 3650/4885MAPK1 4065/4885LMNA 2645/4885 |
| US-20210145822-A1 | Novel Spirolactone Compounds | ACACA, HSD17B10, AKR1C2 | ALDH1A1 43/4885MAPK1 163/4885LMNA 4170/4885 |
| US-20170217891-A1 | ARYL ETHERS AND USES THEREOF | HIF1AN, EGLN2, VHL | ALDH1A1 497/4885MAPK1 3395/4885LMNA 4171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.