Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 16/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | PRTN3 | P24158 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL20679035 | 0.98 | ELANE (0.61) | ELANECA2PRTN3MEN1KMT2A | |
| SCHEMBL22369614 | 0.84 | ELANE (0.86) | ELANEPRTN3 | |
| SCHEMBL23135278 | 0.83 | ELANE (0.66) | ELANEPRTN3MEN1KMT2A | |
| SCHEMBL28702876 | 0.80 | L3MBTL1 (0.68) | ELANECA2MEN1KMT2A | |
| SCHEMBL8395395 | 0.79 | ELANE (0.59) | ELANEPRTN3MEN1KMT2A | |
| SCHEMBL6668735 | 0.79 | ELANE (0.70) | ELANECA2 | |
| SCHEMBL2004186 | 0.79 | MAPT (0.61) | ELANECA2MEN1KMT2A | |
| SCHEMBL13998362 | 0.78 | ELANE (0.76) | ELANEPRTN3 | |
| SCHEMBL10483745 | 0.78 | ELANE (1.00) | ELANEPRTN3 | |
| SCHEMBL8403640 | 0.78 | ELANE (0.81) | ELANEPRTN3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3407916-B1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME LLC (US) | 2023-12-20 | — | — | EP | disclosed |
| US-20230147502-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILIATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME LLC (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230147502-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILIATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME LLC (US) | 2023-05-11 | — | — | US | disclosed |
| US-20210015930-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2021-01-21 | — | — | US | disclosed |
| US-10869929-B2 | Phosphonate linkers and their use to facilitate cellular retention of compounds | MERCK SHARP & DOHME CORP. (US) | 2020-12-22 | — | — | US | disclosed |
| US-20190030171-A1 | PHOSPONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2019-01-31 | — | — | US | disclosed |
| WO-2017132103-A2 | PHOSPHONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230147502-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILIATE CELLULAR RETENTION OF COMPOUNDS | PHOSPHO1, SLC46A1, SLC19A1 | ELANE 1604/4885CA2 2641/4885PRTN3 2903/4885 |
| US-20190030171-A1 | PHOSPONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS | PHOSPHO1, PHPT1, PSPH | ELANE 2888/4885CA2 2662/4885PRTN3 3074/4885 |
| US-20210015930-A1 | PHOSPHONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS | PHOSPHO1, TK1, MSN | ELANE 1598/4885CA2 3765/4885PRTN3 2663/4885 |
| US-10869929-B2 | Phosphonate linkers and their use to facilitate cellular retention of compounds | PHOSPHO1, TK1, MSN | ELANE 1598/4885CA2 3765/4885PRTN3 2663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.