Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 9/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921725 | 0.90 | CRHBP (0.43) | CRHBPCRHR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL1921210 | 0.88 | KEAP1 (0.41) | CRHBPCRHR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL1919868 | 0.87 | CRHBP (0.48) | CRHBPCRHR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL1629345 | 0.87 | CRHBP (0.49) | CRHBPCRHR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL1920350 | 0.86 | MAPT (0.43) | KEAP1NFE2L2ALDH1A1LMNAMAPT | |
| SCHEMBL1920366 | 0.86 | MDM4 (0.42) | KEAP1NFE2L2ALDH1A1LMNAMAPT | |
| SCHEMBL1919930 | 0.86 | MDM4 (0.39) | KEAP1NFE2L2ALDH1A1LMNAMAPT | |
| SCHEMBL1920797 | 0.85 | ALDH1A1 (0.42) | KEAP1NFE2L2ALDH1A1LMNATSHR | |
| SCHEMBL1920825 | 0.85 | KMT2A (0.45) | KEAP1NFE2L2ALDH1A1LMNAMAPT | |
| SCHEMBL1920485 | 0.85 | CRHBP (0.44) | CRHBPCRHR2KEAP1NFE2L2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245006-B1 | SULFONAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-06-01 | — | — | EP | disclosed |