Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 8/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | OXTR | P30559 | 3/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921725 | 0.95 | CRHBP (0.43) | CRHBPCRHR2KEAP1NFE2L2TSHR | |
| SCHEMBL1919868 | 0.92 | CRHBP (0.48) | CRHBPCRHR2KEAP1NFE2L2TSHR | |
| SCHEMBL1921210 | 0.90 | KEAP1 (0.41) | CRHBPCRHR2KEAP1NFE2L2TSHR | |
| SCHEMBL1920870 | 0.88 | OXTR (0.46) | KEAP1NFE2L2ALDH1A1LMNAOXTR | |
| SCHEMBL1920212 | 0.88 | CRHBP (0.44) | CRHBPCRHR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL1629056 | 0.87 | CRHBP (0.56) | CRHBPCRHR2KEAP1NFE2L2TSHR | |
| SCHEMBL1919944 | 0.85 | CRHBP (0.47) | CRHBPCRHR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL1920182 | 0.85 | CRHBP (0.39) | CRHBPCRHR2KEAP1NFE2L2TSHR | |
| SCHEMBL1920350 | 0.85 | MAPT (0.43) | KEAP1NFE2L2ALDH1A1LMNAOXTR | |
| SCHEMBL1920824 | 0.84 | KMT2A (0.43) | KEAP1NFE2L2ALDH1A1LMNAOXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245006-B1 | SULFONAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-06-01 | — | — | EP | disclosed |