Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | ESR1 | P03372 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | TK1 | P04183 | 5/20 | 0.50 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | ALB | P02768 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784500 | 1.00 | LMNA (0.69) | LMNAALDH1A1POLBESR1MAPT | |
| SCHEMBL9839754 | 1.00 | LMNA (0.69) | LMNAALDH1A1POLBESR1MAPT | |
| SCHEMBL9839633 | 0.85 | ALDH1A1 (0.51) | LMNAALDH1A1POLBESR1MAPT | |
| Tegafur SCHEMBL4552 | 0.82 | LMNA (1.00) | LMNAALDH1A1POLBESR1MAPT | |
| SCHEMBL9838290 | 0.82 | ALDH1A1 (0.69) | LMNAALDH1A1POLBESR1MAPT | |
| Tegafur SCHEMBL8537231 | 0.82 | LMNA (1.00) | LMNAALDH1A1POLBESR1MAPT | |
| SCHEMBL9841253 | 0.82 | KMT2A (1.00) | LMNAALDH1A1POLBESR1MAPT | |
| Tegafur SCHEMBL4553 | 0.82 | LMNA (1.00) | LMNAALDH1A1POLBESR1MAPT | |
| Tegafur SCHEMBL7698456 | 0.82 | LMNA (1.00) | LMNAALDH1A1POLBESR1MAPT | |
| Tegafur SCHEMBL22320166 | 0.81 | LMNA (0.97) | LMNAALDH1A1POLBESR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10940150-B2 | Thymine derivatives and quinazoline-dione derivatives for the inhibition of HSP27 | TECHNISCHE UNIVERSITAET DRESDEN (DE) | 2021-03-09 | — | — | US | disclosed |
| US-20180207160-A1 | THYMINE DERIVATIVES AND QUINAZOLINE-DIONE DERIVATIVES FOR THE INHIBITION OF HSP27 | TECHNISCHE UNIVERSITAET DRESDEN (DE) | 2018-07-26 | — | — | US | disclosed |
| US-20170216297-A1 | EFFICIENT INHIBITION OF HSP27 | TECHNISCHE UNIVERSITAET DRESDEN (DE) | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180207160-A1 | THYMINE DERIVATIVES AND QUINAZOLINE-DIONE DERIVATIVES FOR THE INHIBITION OF HSP27 | HSPB1, HSP90B1, HSP90AB1 | LMNA 4404/4885ALDH1A1 1242/4885POLB 628/4885 |
| US-20170216297-A1 | EFFICIENT INHIBITION OF HSP27 | HSPB1, HSP90AB2P, HSP90B1 | LMNA 4242/4885ALDH1A1 1077/4885POLB 842/4885 |
| US-10940150-B2 | Thymine derivatives and quinazoline-dione derivatives for the inhibition of HSP27 | HSPB1, HSP90B1, HSP90AB1 | LMNA 4404/4885ALDH1A1 1242/4885POLB 628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.