Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | OXTR | P30559 | 4/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MDM4 | O15151 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920212 | 0.98 | CRHBP (0.44) | CRHBPCRHR2OXTRAVPR1ANPSR1 | |
| SCHEMBL1920870 | 0.94 | OXTR (0.46) | OXTRAVPR1ANPSR1PKMMAPT | |
| SCHEMBL1920294 | 0.92 | MDM4 (0.48) | CRHBPCRHR2OXTRAVPR1ANPSR1 | |
| SCHEMBL1920350 | 0.91 | MAPT (0.43) | OXTRAVPR1ANPSR1PKMMDM4 | |
| SCHEMBL1920502 | 0.89 | LMNA (0.41) | CRHBPCRHR2NPSR1PSEN1PSEN2 | |
| SCHEMBL1920366 | 0.88 | MDM4 (0.42) | OXTRAVPR1ANPSR1PKMMDM4 | |
| SCHEMBL1919721 | 0.88 | CRHBP (0.38) | CRHBPCRHR2OXTRAVPR1APSEN1 | |
| SCHEMBL1920213 | 0.87 | KMT2A (0.41) | CRHBPCRHR2OXTRAVPR1ANPSR1 | |
| SCHEMBL1920221 | 0.86 | CRHBP (0.40) | CRHBPCRHR2NPSR1PSEN1PSEN2 | |
| SCHEMBL1920824 | 0.86 | KMT2A (0.43) | OXTRAVPR1ANPSR1PKMMDM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245006-B1 | SULFONAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-06-01 | — | — | EP | disclosed |