Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 3/20 | 0.31 |
| ▸ | FPR1 | P21462 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19255760 | 0.78 | CASP1 (0.48) | — | |
| SCHEMBL4512895 | 0.75 | HSD11B1 (0.43) | FPR2 | |
| SCHEMBL19255648 | 0.75 | RIPK1 (0.42) | — | |
| SCHEMBL19224398 | 0.75 | RIPK1 (0.42) | — | |
| SCHEMBL19207651 | 0.75 | RIPK1 (0.42) | — | |
| SCHEMBL20050166 | 0.74 | TYK2 (0.30) | — | |
| SCHEMBL17497521 | 0.74 | TDP1 (0.37) | TDP1 | |
| SCHEMBL17497523 | 0.74 | TDP1 (0.37) | TDP1 | |
| SCHEMBL17497605 | 0.74 | TDP1 (0.37) | TDP1 | |
| Hydrochloric Acid SCHEMBL2598384 | 0.72 | FPR2 (0.50) | FPR2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414239-A2 | INHIBITORS OF RECEPTOR-INTERACTING PROTEIN KINASE 1 | Denali Therapeutics Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |