Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | OXTR | P30559 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921417 | 0.89 | DPP4 (0.37) | LMNAUTS2RHSD11B1NPSR1POLB | |
| SCHEMBL1920487 | 0.88 | UTS2R (0.37) | LMNAUTS2RHSD11B1NPSR1POLB | |
| SCHEMBL1629076 | 0.86 | LMNA (0.50) | LMNAUTS2RADAM17HSD11B1NPSR1 | |
| SCHEMBL1920502 | 0.84 | LMNA (0.41) | LMNAUTS2RADAM17HSD11B1NPSR1 | |
| SCHEMBL1921722 | 0.83 | UTS2R (0.38) | LMNAUTS2RHSD11B1CRHBPCRHR2 | |
| SCHEMBL1920311 | 0.83 | CRHBP (0.34) | LMNAUTS2RNPSR1POLBCRHBP | |
| SCHEMBL1630544 | 0.83 | HSD11B1 (0.47) | UTS2RHSD11B1NPSR1POLBHTT | |
| SCHEMBL3427591 | 0.83 | UTS2R (0.41) | LMNAUTS2RHSD11B1NPSR1POLB | |
| SCHEMBL1920310 | 0.81 | CRHBP (0.40) | LMNANPSR1POLBHTTCRHBP | |
| SCHEMBL3427813 | 0.81 | KMT2A (0.53) | LMNANPSR1HTTCRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245006-B1 | SULFONAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-06-01 | — | — | EP | disclosed |