Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920221 | 0.93 | CRHBP (0.40) | LMNACRHBPCRHR2HSD11B1UTS2R | |
| SCHEMBL1920213 | 0.93 | KMT2A (0.41) | LMNACRHBPCRHR2UTS2RPSEN1 | |
| SCHEMBL1920212 | 0.91 | CRHBP (0.44) | LMNACRHBPCRHR2PSEN1PSEN2 | |
| SCHEMBL1919721 | 0.90 | CRHBP (0.38) | LMNACRHBPCRHR2UTS2RPSEN1 | |
| SCHEMBL1919944 | 0.89 | CRHBP (0.47) | LMNACRHBPCRHR2PSEN1PSEN2 | |
| SCHEMBL1920870 | 0.87 | OXTR (0.46) | LMNANPSR1HTTPOLBKMT2A | |
| SCHEMBL1920294 | 0.85 | MDM4 (0.48) | LMNACRHBPCRHR2PSEN1PSEN2 | |
| SCHEMBL1921822 | 0.85 | MDM4 (0.40) | LMNACRHBPCRHR2PSEN1PSEN2 | |
| SCHEMBL1630616 | 0.85 | CRHBP (0.53) | LMNACRHBPCRHR2HSD11B1UTS2R | |
| SCHEMBL1920802 | 0.84 | LMNA (0.39) | LMNACRHBPCRHR2HSD11B1UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245006-B1 | SULFONAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-06-01 | — | — | EP | disclosed |