Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4688913 | 0.86 | CYP1A2 (0.76) | CYP1A2CYP2C9CYP2C19MAPTLMNA | |
| SCHEMBL2898307 | 0.80 | CYP1A2 (0.75) | CYP1A2CYP2C9CYP2C19MAPTLMNA | |
| SCHEMBL14818765 | 0.76 | EPHX2 (0.54) | CYP1A2EPHX2CHRNB2CHRNA4PRKCI | |
| SCHEMBL2488542 | 0.73 | OPRK1 (0.55) | CYP1A2CYP2C9CYP2C19PRKCAPRKCQ | |
| SCHEMBL2004470 | 0.72 | DRD2 (0.53) | MAPTEPHX2CHRNB2CHRNA4 | |
| SCHEMBL19853561 | 0.72 | EPHX2 (0.50) | MAPTEPHX2CHRNB2CHRNA4HTR2C | |
| SCHEMBL12986602 | 0.72 | HTR3A (0.51) | CYP2C19MAPTEPHX2LMNACHRNB2 | |
| SCHEMBL14803888 | 0.72 | EPHX2 (0.65) | EPHX2CHRNB2CHRNA4HTR2CROCK2 | |
| SCHEMBL5356587 | 0.72 | EPHX2 (0.89) | MAPTEPHX2 | |
| SCHEMBL8919927 | 0.72 | HTR2C (0.62) | MAPTEPHX2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170226124-A1 | PHTHALAZINONE DERIVATIVES | KUDOS PHARMACEUTICALS LIMITED (GB) | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226124-A1 | PHTHALAZINONE DERIVATIVES | NR0B1, NR0B2, NR2E1 | CYP1A2 548/4885CYP2C9 1361/4885CYP2C19 970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.