Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.44 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.44 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6555490 | 0.90 | L3MBTL1 (0.48) | L3MBTL1ADORA2AMEN1KMT2ABRCA1 | |
| SCHEMBL6918767 | 0.86 | L3MBTL1 (0.52) | L3MBTL1ADORA2AMEN1KMT2ABRCA1 | |
| SCHEMBL13984089 | 0.84 | L3MBTL1 (0.41) | L3MBTL1ADORA2AMEN1KMT2ABRCA1 | |
| SCHEMBL2554376 | 0.82 | L3MBTL1 (0.74) | L3MBTL1ADORA2AMEN1KMT2ABRCA1 | |
| SCHEMBL516264 | 0.78 | PLA2G1B (0.41) | L3MBTL1ADORA2AMEN1KMT2AALDH1A1 | |
| SCHEMBL1922260 | 0.77 | PLA2G1B (0.43) | L3MBTL1ADORA2AMEN1KMT2ABRCA1 | |
| SCHEMBL623740 | 0.76 | ADORA2A (0.71) | L3MBTL1ADORA2AMEN1KMT2AALDH1A1 | |
| SCHEMBL10508850 | 0.74 | ADORA2A (0.49) | L3MBTL1ADORA2AMEN1KMT2ABRCA1 | |
| SCHEMBL3050182 | 0.73 | ADORA2A (0.55) | L3MBTL1ADORA2AMEN1KMT2AALDH1A1 | |
| SCHEMBL1289601 | 0.73 | L3MBTL1 (0.41) | L3MBTL1ADORA2AMEN1KMT2ABRCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175270-A1 | IMPROVED PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE HYDRATES AND NEW POLYMORPHIC FORM OF MONOHYDRATE | FLEMING LABORATORIES LIMITED (IN) | 2013-11-28 | — | — | WO | claimed |
| EP-2328884-A2 | A PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE | Glenmark Generics Limited (IN) | 2011-06-08 | — | — | EP | claimed |
| WO-2010021000-A2 | A PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE | GLENMARK GENERICS LIMITED (IN) | 2010-02-25 | — | — | WO | claimed |
| US-20060142596-A1 | Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | LES LABORATOIRES SERVIER (FR) | 2006-06-29 | — | — | US | claimed |
| EP-1403264-B1 | Process for the industrial synthesis of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxydimethylester | SERVIER LAB (FR) | 2004-12-29 | — | — | EP | claimed |
| US-20040059135-A1 | Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | LES LABORATOIRES SERVIER (FR) | 2004-03-25 | — | — | US | claimed |
| WO-2013175270-A1 | IMPROVED PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE HYDRATES AND NEW POLYMORPHIC FORM OF MONOHYDRATE | FLEMING LABORATORIES LIMITED (IN) | 2013-11-28 | — | — | WO | disclosed |
| US-20120123131-A1 | PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE | PRABAHAR KOILPILLAI JOSEPH (IN) | 2012-05-17 | — | — | US | disclosed |
| EP-2328884-A2 | A PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE | Glenmark Generics Limited (IN) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010021000-A2 | A PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE | GLENMARK GENERICS LIMITED (IN) | 2010-02-25 | — | — | WO | disclosed |
| US-7462714-B2 | Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | LES LABORATOIRES SERVIER (FR) | 2008-12-09 | — | — | US | disclosed |
| US-7462714-B2 | Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | LES LABORATOIRES SERVIER (FR) | 2008-12-09 | — | — | US | disclosed |
| US-7462714-B2 | Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | LES LABORATOIRES SERVIER (FR) | 2008-12-09 | — | — | US | disclosed |
| US-7105683-B2 | Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | LES LABORATOIRES SERVIER (FR) | 2006-09-12 | — | — | US | disclosed |
| US-20060142567-A1 | Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | LES LABORATOIRES SERVIER (FR) | 2006-06-29 | — | — | US | disclosed |
| US-20060142596-A1 | Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | LES LABORATOIRES SERVIER (FR) | 2006-06-29 | — | — | US | disclosed |
| JP-2004269495-A | INDUSTRIAL SYNTHESIS OF METHYL DIESTER OF 5-AMINO-3-CARBOXYMETHYL-4-CYANO-2-THIOPHENECARBOXYLIC ACID AND USE FOR SYNTHESIS OF (HYDRATED) BIVALENT SALT OF RANELIC ACID | LAB SERVIER | 2004-09-30 | — | — | JP | disclosed |
| US-20040063972-A1 | Process for the industrial synthesis of strontium ranelate and its hydrates | LES LABORATOIRES SERVIER (FR) | 2004-04-01 | — | — | US | disclosed |
| EP-1403264-A1 | Process for the industrial synthesis of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxydimethylester | Les Laboratoires Servier (FR) | 2004-03-31 | — | — | EP | disclosed |
| US-20040059135-A1 | Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | LES LABORATOIRES SERVIER (FR) | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063972-A1 | Process for the industrial synthesis of strontium ranelate and its hydrates | STAU1, SF1, CYP51A1 | L3MBTL1 4527/4885ADORA2A 4645/4885MEN1 733/4885 |
| US-20040059135-A1 | Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | CA7, CA2, SLC38A7 | L3MBTL1 4793/4885ADORA2A 727/4885MEN1 2632/4885 |
| US-20060142596-A1 | Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | CA7, CA2, DNMT1 | L3MBTL1 4826/4885ADORA2A 738/4885MEN1 2621/4885 |
| US-20120123131-A1 | PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE | C1S, RANBP1, C5 | L3MBTL1 4008/4885ADORA2A 3056/4885MEN1 333/4885 |
| US-20060142567-A1 | Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates | CA7, CA2, DNMT1 | L3MBTL1 4826/4885ADORA2A 738/4885MEN1 2621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.