Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1922633 | 1.00 | CTSK (0.47) | CTSKCTSLCTSSCTSBCA1 | |
| SCHEMBL1922634 | 1.00 | CTSK (0.47) | CTSKCTSLCTSSCTSBCA1 | |
| SCHEMBL1922636 | 1.00 | CTSK (0.47) | CTSKCTSLCTSSCTSBCA1 | |
| SCHEMBL10420922 | 0.89 | CTSK (0.47) | CTSKCTSLCTSSCTSBCA1 | |
| SCHEMBL8034346 | 0.88 | CTSK (0.49) | CTSKCTSLCTSSCTSBCA1 | |
| SCHEMBL10545929 | 0.88 | CTSK (0.49) | CTSKCTSLCTSSCTSBCA1 | |
| SCHEMBL16480228 | 0.85 | CTSK (0.49) | CTSKCTSLCTSSCTSBCA1 | |
| SCHEMBL7435374 | 0.85 | CTSK (0.52) | CTSKCTSLCTSSCTSBCA1 | |
| SCHEMBL7435372 | 0.85 | CTSK (0.52) | CTSKCTSLCTSSCTSBCA1 | |
| SCHEMBL9556266 | 0.85 | CTSK (0.52) | CTSKCTSLCTSSCTSBCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230144767-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2023-05-11 | — | — | US | disclosed |
| US-20210371460-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-12-02 | — | — | US | disclosed |
| US-20200317730-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-10-08 | — | — | US | disclosed |
| US-20190210969-A1 | INTRAESOPHAGEAL ADMINISTRATION OF TARGETED NITROXIDE AGENTS FOR PROTECTION AGAINST IONIZING IRRADIATION-INDUCED ESOPHAGITIS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2019-07-11 | — | — | US | disclosed |
| US-20180298054-A1 | TARGETED NITROXIDE AGENTS | University of Pittsburgh - of the Commonwealth Sys tem of Higher Education (US) | 2018-10-18 | — | — | US | disclosed |
| US-9890192-B2 | Targeted nitroxide agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2018-02-13 | — | — | US | disclosed |
| US-20160137692-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-05-19 | — | — | US | disclosed |
| US-9216976-B2 | Targeted nitroxide agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-12-22 | — | — | US | disclosed |
| US-20140378444-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-12-25 | — | — | US | disclosed |
| EP-2328875-B1 | TARGETED NITROXIDE AGENTS | UNIV PITTSBURGH (US) | 2014-10-15 | — | — | EP | disclosed |
| US-8609850-B2 | Targeted nitroxide agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2013-12-17 | — | — | US | disclosed |
| US-20130102626-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2013-04-25 | — | — | US | disclosed |
| US-8288551-B2 | Targeted nitroxide agents | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-10-16 | — | — | US | disclosed |
| WO-2012068081-A1 | INTRAESOPHAGEAL ADMINISTRATION OF TARGETED NITROXIDE AGENTS FOR PROTECTION AGAINST IONIZING IRRADIATION-INDUCED ESOPHAGATIS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-05-24 | — | — | WO | disclosed |
| US-20110172214-A1 | USE OF TARGETED NITROXIDE AGENTS IN PREVENTING, MITIGATING AND TREATING RADIATION INJURY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2011-07-14 | — | — | US | disclosed |
| EP-2328875-A2 | TARGETED NITROXIDE AGENTS | University of Pittsburgh - Of the Commonwealth System of Higher Education (US) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010009405-A9 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2010-03-25 | — | — | WO | disclosed |
| US-20100035869-A1 | TARGETED NITROXIDE AGENTS | PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UNIVERSITY OF | 2010-02-11 | — | — | US | disclosed |
| WO-2010009389-A1 | USE OF TARGETED NITROXIDE AGENTS IN PREVENTING, MITIGATING AND TREATING RADIATION INJURY | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2010-01-21 | — | — | WO | disclosed |
| WO-2010009405-A2 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2010-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172214-A1 | USE OF TARGETED NITROXIDE AGENTS IN PREVENTING, MITIGATING AND TREATING RADIATION INJURY | TXNRD2, TXN2, HSPE1 | CTSK 2223/4885CTSL 3648/4885CTSS 2157/4885 |
| US-20190210969-A1 | INTRAESOPHAGEAL ADMINISTRATION OF TARGETED NITROXIDE AGENTS FOR PROTECTION AGAINST IONIZING IRRADIATION-INDUCED ESOPHAGITIS | HSPE1, HSPA9, HSPD1 | CTSK 3108/4885CTSL 3865/4885CTSS 3013/4885 |
| US-20160137692-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | CTSK 3049/4885CTSL 4201/4885CTSS 3039/4885 |
| US-20180298054-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | CTSK 3049/4885CTSL 4201/4885CTSS 3039/4885 |
| US-20200317730-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | CTSK 3049/4885CTSL 4201/4885CTSS 3039/4885 |
| US-20100035869-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | CTSK 3049/4885CTSL 4201/4885CTSS 3039/4885 |
| US-20230144767-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | CTSK 3049/4885CTSL 4201/4885CTSS 3039/4885 |
| US-20140378444-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | CTSK 3049/4885CTSL 4201/4885CTSS 3039/4885 |
| US-20210371460-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | CTSK 3049/4885CTSL 4201/4885CTSS 3039/4885 |
| US-20130102626-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | CTSK 3049/4885CTSL 4201/4885CTSS 3039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.