Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.58 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.58 |
| ▸ | TYR | P14679 | 3/20 | 0.52 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1649282 | 0.82 | ALDH1A1 (0.62) | HSP90AA1HSP90AB1RNASEH1ALDH1A1ALOX12 | |
| SCHEMBL29495445 | 0.82 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1TYRRNASEH1ALDH1A1 | |
| SCHEMBL2354241 | 0.82 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1TYRRNASEH1ALDH1A1 | |
| SCHEMBL24413664 | 0.81 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1TYRRNASEH1ALDH1A1 | |
| SCHEMBL14570448 | 0.81 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1TYRRNASEH1ALDH1A1 | |
| SCHEMBL19236879 | 0.79 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1TYRRNASEH1HIF1A | |
| SCHEMBL21786696 | 0.78 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1TYRRNASEH1ALDH1A1 | |
| SCHEMBL27778658 | 0.78 | HSP90AB1 (0.64) | HSP90AA1HSP90AB1TYRRNASEH1ALDH1A1 | |
| SCHEMBL18557372 | 0.77 | PTGS1 (0.47) | HSP90AA1HSP90AB1RNASEH1HIF1ATRPA1 | |
| SCHEMBL19236936 | 0.77 | HPGD (0.51) | HSP90AA1HSP90AB1ALDH1A1HTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240068009-A1 | SUBSTITUTED IMIDAZO[1,2-a]PYRAZINES AS LUCIFERASE SUBSTRATES | PROMEGA CORPORATION | 2024-02-29 | — | — | US | disclosed |
| US-11781168-B2 | Process for preparing substituted imidazo[1,2-α]pyrazines | PROMEGA CORPORATION (US) | 2023-10-10 | — | — | US | disclosed |
| US-10669568-B2 | Substituted imidazo[1,2-a]pyrazines as luciferase substrates | PROMEGA CORPORATION (US) | 2020-06-02 | — | — | US | disclosed |
| US-20190241932-A1 | COELENTERAZINE ANALOGUES | PROMEGA CORPORATION | 2019-08-08 | — | — | US | disclosed |
| US-9924073-B2 | Substituted imidazo[1,2-a]pyrazines as luciferase substrates and preparation method thereof | PROMEGA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |
| US-20170233789-A1 | COELENTERAZINE ANALOGUES | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11781168-B2 | Process for preparing substituted imidazo[1,2-α]pyrazines | CYP4Z1, CYP2E1, CYP2F1 | HSP90AA1 1928/4885HSP90AB1 1798/4885TYR 478/4885 |
| US-20190241932-A1 | COELENTERAZINE ANALOGUES | GLB1, SI, TCF7L2 | HSP90AA1 2594/4885HSP90AB1 2476/4885TYR 327/4885 |
| US-20170233789-A1 | COELENTERAZINE ANALOGUES | GLB1, SI, TCF7L2 | HSP90AA1 2594/4885HSP90AB1 2476/4885TYR 327/4885 |
| US-20240068009-A1 | SUBSTITUTED IMIDAZO[1,2-a]PYRAZINES AS LUCIFERASE SUBSTRATES | PGLS, AADAC, GLB1 | HSP90AA1 2736/4885HSP90AB1 3476/4885TYR 1583/4885 |
| US-10669568-B2 | Substituted imidazo[1,2-a]pyrazines as luciferase substrates | AADAC, PGLS, GLB1 | HSP90AA1 2801/4885HSP90AB1 3519/4885TYR 1487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.