Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.60 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.60 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.53 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | TYR | P14679 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29495445 | 1.00 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1TRPA1PTGS1CACNA1C | |
| SCHEMBL3210024 | 0.84 | TRPA1 (0.53) | HSP90AA1HSP90AB1TRPA1PTGS1CACNA1C | |
| SCHEMBL1649282 | 0.84 | ALDH1A1 (0.62) | HSP90AA1HSP90AB1RNASEH1ALDH1A1ALOX12 | |
| SCHEMBL30953697 | 0.84 | PLG (0.54) | HSP90AA1HSP90AB1TRPA1PTGS1CACNA1C | |
| SCHEMBL1261130 | 0.84 | PLG (0.54) | HSP90AA1HSP90AB1TRPA1PTGS1CACNA1C | |
| SCHEMBL1679635 | 0.83 | AKR1C3 (0.49) | HSP90AA1HSP90AB1PTGS1ALDH1A1KDM4E | |
| SCHEMBL24413664 | 0.82 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1TRPA1PTGS1CACNA1C | |
| SCHEMBL14570448 | 0.82 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1TRPA1PTGS1CACNA1C | |
| SCHEMBL19236830 | 0.82 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1TRPA1PTGS1CACNA1C | |
| SCHEMBL9908617 | 0.82 | ALDH1A1 (0.57) | HSP90AA1HSP90AB1ALDH1A1ALOX12HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114702374-A | Preparation method of amlexanox intermediate | 山东科源制药股份有限公司 | 2022-07-05 | — | — | CN | claimed |
| US-20240018133-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2024-01-18 | — | — | US | disclosed |
| US-11873291-B2 | Quinoline cGAS antagonist compounds | IMMUNESENSOR THERAPEUTICS, INC. (US) | 2024-01-16 | — | — | US | disclosed |
| US-20230357158-A1 | QUINOLINE cGAS ANTAGONIST COMPOUNDS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2023-11-09 | — | — | US | disclosed |
| CN-114702374-A | Preparation method of amlexanox intermediate | 山东科源制药股份有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-114702374-A | Preparation method of amlexanox intermediate | 山东科源制药股份有限公司 | 2022-07-05 | — | — | CN | disclosed |
| US-20210363136-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2021-11-25 | — | — | US | disclosed |
| WO-2021085372-A1 | RESIN COMPOSITION, COMPOUND (Z), OPTICAL FILTER, AND USE THEREOF | JSR株式会社 | 2021-05-06 | — | — | WO | disclosed |
| WO-2020223536-A1 | SUBSTITUTED CYCLOLAKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2020-11-05 | — | — | WO | disclosed |
| US-9744164-B2 | Neuroprotective polyphenol analogs | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2017-08-29 | — | — | US | disclosed |
| EP-0716088-B1 | PROCESS FOR PRODUCING 2-(TETRAZOL-5-YL)-4-OXO-4H-BENZOPYRANS | SUMITOMO CHEMICAL CO (JP) | 2004-02-18 | — | — | EP | disclosed |
| US-6479671-B1 | Process for producing optically active chromene derivative | SHIONOGI & CO., LTD. (JP) | 2002-11-12 | — | — | US | disclosed |
| US-6218427-B1 | AS ENDOTHELIN RECEPTOR ANTAGONIST | SHIONOGI & CO., LTD. (JP) | 2001-04-17 | — | — | US | disclosed |
| EP-1057824-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE CHROMENE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |
| EP-0924207-A1 | CHROMENE-3-CARBOXYLATE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 1999-06-23 | — | — | EP | disclosed |
| US-5597929-A | Production process of 2-(tetrazol-5-yl)-4-oxo-4H-benzopyran | SUMITOMO CHEMICAL CO., LTD. (JP) | 1997-01-28 | — | — | US | disclosed |
| EP-0716088-A1 | PROCESS FOR PRODUCING 2-(TETRAZOL-5-YL)-4-OXO-4H-BENZOPYRANS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1996-06-12 | — | — | EP | disclosed |
| US-4058532-A | 1-Phenyl-3,4-dihydrocarbostyrils | STERLING DRUG INC. (US) | 1977-11-15 | — | — | US | disclosed |
| US-4049715-A | 3-[2-(4-Anisidino)phenyl]-1-phenyl-1-propiophenones and propanols | STERLING DRUG INC. (US) | 1977-09-20 | — | — | US | disclosed |
| US-3994902-A | Certain 1,2-diphenyl-1,2,3,4-tetrahydroquinoline compounds | STERLING DRUG INC. (US) | 1976-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210363136-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | HSP90AA1 244/4885HSP90AB1 150/4885TRPA1 2121/4885 |
| US-11873291-B2 | Quinoline cGAS antagonist compounds | CGAS, GLS2, GLS | HSP90AA1 2754/4885HSP90AB1 2412/4885TRPA1 3301/4885 |
| US-20240018133-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | HSP90AA1 244/4885HSP90AB1 150/4885TRPA1 2121/4885 |
| US-20230357158-A1 | QUINOLINE cGAS ANTAGONIST COMPOUNDS | CGAS, GLS2, GLS | HSP90AA1 2754/4885HSP90AB1 2412/4885TRPA1 3301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.