Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.50 |
| ▸ | MEN1 | O00255 | 11/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.50 |
| ▸ | LMNA | P02545 | 9/20 | 0.50 |
| ▸ | HTT | P42858 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1925482 | 0.86 | STING1 (0.44) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL1924127 | 0.85 | MAPT (0.52) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL1924361 | 0.83 | KMT2A (0.46) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL1924893 | 0.81 | KDR (0.51) | — | |
| SCHEMBL1925173 | 0.80 | MAPT (0.47) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL1924464 | 0.80 | ALDH1A1 (0.38) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL1925038 | 0.79 | ROCK2 (0.46) | MAPTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL1924876 | 0.79 | AKT2 (0.42) | MEN1KMT2ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL1923912 | 0.78 | KDR (0.48) | MAPTMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL1924884 | 0.78 | MEN1 (0.42) | MAPTMEN1KMT2ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856043-B1 | 1-H-PYRROLE-2-CARBOXAMIDES AND IMIDAZOLE-5-CARBOXAMIDES AND USE THEREOF AS FAK, KDR AND TIE2 KINASE MODULATORS FOR THE TREATMENT OF CANCER | AVENTIS PHARMA SA (FR) | 2011-06-08 | — | — | EP | claimed |