Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1926602 | 0.87 | KDM4E (0.46) | MAPTMEN1KMT2ASMN1; SMN2POLB | |
| SCHEMBL1923925 | 0.86 | MAPT (0.50) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL1924602 | 0.86 | EPHX2 (0.49) | STING1MAPTMEN1KMT2AHTT | |
| SCHEMBL1924464 | 0.86 | ALDH1A1 (0.38) | STING1MAPTMEN1KMT2AHTT | |
| SCHEMBL1923912 | 0.83 | KDR (0.48) | STING1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1925334 | 0.83 | EPHX2 (0.48) | STING1MAPTMEN1KMT2AKDR | |
| SCHEMBL1925481 | 0.83 | STING1 (0.47) | STING1MAPTMEN1KMT2ALMNA | |
| SCHEMBL1926895 | 0.82 | MAPT (0.41) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL1924884 | 0.81 | MEN1 (0.42) | MAPTMEN1KMT2ASMN1; SMN2POLB | |
| SCHEMBL1925337 | 0.80 | PKM (0.47) | MAPTMEN1KMT2ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856043-B1 | 1-H-PYRROLE-2-CARBOXAMIDES AND IMIDAZOLE-5-CARBOXAMIDES AND USE THEREOF AS FAK, KDR AND TIE2 KINASE MODULATORS FOR THE TREATMENT OF CANCER | AVENTIS PHARMA SA (FR) | 2011-06-08 | — | — | EP | claimed |