Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | AGXT | P21549 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18297917 | 0.78 | TSHR (0.48) | TSHRIDO1TP53AGXTALDH1A1 | |
| SCHEMBL28128704 | 0.74 | TSHR (0.48) | TSHRIDO1AGXTALDH1A1L3MBTL1 | |
| SCHEMBL177923 | 0.74 | TSHR (0.67) | TSHRIDO1TP53AGXTALDH1A1 | |
| Alcohol SCHEMBL5269265 | 0.73 | TSHR (0.52) | TSHRIDO1TP53AGXTALDH1A1 | |
| SCHEMBL2435561 | 0.73 | TSHR (0.52) | TSHRIDO1TP53AGXTALDH1A1 | |
| SCHEMBL11117973 | 0.72 | TSHR (0.46) | TSHRIDO1AGXTALDH1A1L3MBTL1 | |
| Phosphine SCHEMBL28182122 | 0.72 | TSHR (0.46) | TSHRIDO1AGXTALDH1A1L3MBTL1 | |
| SCHEMBL28604988 | 0.72 | TSHR (0.41) | TSHRIDO1TP53AGXTALDH1A1 | |
| SCHEMBL28045261 | 0.72 | IDO1 (0.43) | TSHRIDO1TP53AGXTALDH1A1 | |
| Water SCHEMBL28419682 | 0.71 | TSHR (0.63) | TSHRIDO1TP53AGXTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3419982-B1 | NEW STABLE SILYLATING REAGENTS | CALIFORNIA INST OF TECHN (US) | 2023-11-15 | — | — | EP | disclosed |
| US-20210323983-A1 | STABLE SILYLATING REAGENTS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2021-10-21 | — | — | US | disclosed |
| US-11028107-B2 | Stable silylating reagents | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2021-06-08 | — | — | US | disclosed |
| EP-3419982-A1 | NEW STABLE SILYLATING REAGENTS | California Institute of Technology (US) | 2019-01-02 | — | — | EP | disclosed |
| CN-108699089-A | Novel stable silylating agents | 加州理工学院 | 2018-10-23 | — | — | CN | disclosed |
| WO-2017147110-A1 | NEW STABLE SILYLATING REAGENTS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-08-31 | — | — | WO | disclosed |
| US-20170240571-A1 | STABLE SILYLATING REAGENTS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2017-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323983-A1 | STABLE SILYLATING REAGENTS | KCNH3, KCNH2, KCNH1 | TSHR 4861/4885IDO1 1651/4885TP53 3368/4885 |
| US-11028107-B2 | Stable silylating reagents | OGDH, CD44, SOD1 | TSHR 4878/4885IDO1 879/4885TP53 2718/4885 |
| US-20170240571-A1 | STABLE SILYLATING REAGENTS | OGDH, CD44, SOD1 | TSHR 4878/4885IDO1 879/4885TP53 2718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.