Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 2/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 5/20 | 0.38 |
| ▸ | RXRA | P19793 | 4/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.34 |
| ▸ | GLRB | P48167 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CCR9 | P51686 | 3/20 | 0.33 |
| ▸ | ASPH | Q12797 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14755583 | 0.85 | LRRK2 (0.39) | GRNSORT1KDM4EALDH1A1TSHR | |
| SCHEMBL23012611 | 0.80 | ASPH (0.44) | SORT1KDM4ERXRBRXRARXRG | |
| SCHEMBL29488332 | 0.80 | ASPH (0.44) | SORT1KDM4ERXRBRXRARXRG | |
| SCHEMBL14948629 | 0.77 | ALOX15 (0.54) | KDM4ERXRBRXRARXRGSRD5A2 | |
| SCHEMBL26818230 | 0.72 | GABRA1 (0.41) | KDM4EALDH1A1ALOX15TDP1CCR9 | |
| SCHEMBL19297940 | 0.72 | HCAR2 (0.47) | KDM4EALDH1A1HCAR2ALOX15TSHR | |
| SCHEMBL2054583 | 0.71 | ALDH1A1 (0.55) | KDM4ERXRBRXRARXRGSRD5A2 | |
| SCHEMBL29538013 | 0.71 | ALDH1A1 (0.55) | KDM4ERXRBRXRARXRGSRD5A2 | |
| SCHEMBL163851 | 0.70 | ALOX15 (0.39) | KDM4EALDH1A1HCAR2ALOX15TSHR | |
| SCHEMBL5593032 | 0.70 | TSHR (0.56) | KDM4EALDH1A1HCAR2ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170240586-A1 | Benzoic Acid Derivatives of Bile Acid as FXR/TGR5 Agonists and Methods of Use Thereof | ENANTA PHARMACEUTICALS, INC. | 2017-08-24 | — | — | US | disclosed |
| US-20170240586-A1 | Benzoic Acid Derivatives of Bile Acid as FXR/TGR5 Agonists and Methods of Use Thereof | ENANTA PHARMACEUTICALS, INC. | 2017-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170240586-A1 | Benzoic Acid Derivatives of Bile Acid as FXR/TGR5 Agonists and Methods of Use Thereof | GPBAR1, NR1H4, SLC10A1 | GRN 1677/4885SORT1 2264/4885KDM4E 3890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.