Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ECE1 | P42892 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19286750 | 0.89 | CTSB (0.37) | CTSBCTSKCTSLCTSSMMP9 | |
| SCHEMBL20121890 | 0.88 | MEN1 (0.37) | CTSBCTSKCTSLCTSSMEN1 | |
| SCHEMBL24040106 | 0.88 | CTSB (0.40) | CTSBCTSKCTSLCTSSMMP9 | |
| SCHEMBL21849676 | 0.86 | TPSAB1 (0.39) | CTSBCTSKCTSLCTSSMEN1 | |
| SCHEMBL24235064 | 0.84 | LTA4H (0.39) | CTSBCTSKCTSLCTSSMEN1 | |
| SCHEMBL19719340 | 0.83 | MEN1 (0.34) | CTSBCTSKCTSLCTSSMEN1 | |
| SCHEMBL19884607 | 0.81 | TPSAB1 (0.41) | CTSBCTSKCTSLCTSSMEN1 | |
| SCHEMBL25790651 | 0.81 | CTSB (0.46) | CTSBCTSKCTSLCTSSMMP9 | |
| SCHEMBL25564557 | 0.81 | FAP (0.38) | MEN1LMNAKMT2A | |
| SCHEMBL25833845 | 0.78 | FAP (0.40) | CTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745334-B2 | Cytotoxic-drug delivering molecules targeting HIV (CDM-Hs), cytotoxic activity against the human immunodeficiency virus and methods of use | YALE UNIVERSITY (US) | 2017-08-29 | — | — | US | disclosed |