Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.66 |
| ▸ | MAPT | P10636 | 10/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18431149 | 1.00 | ALDH1A1 (0.66) | ALDH1A1MAPTSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL21225472 | 0.80 | ALDH1A1 (0.62) | ALDH1A1MAPTSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL4334391 | 0.77 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL4334387 | 0.77 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL2760337 | 0.73 | POLB (0.60) | ALDH1A1MAPTSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL15765079 | 0.73 | NR1H4 (0.71) | ALDH1A1MAPTSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL31380195 | 0.70 | POLB (0.56) | ALDH1A1MAPTSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL19298013 | 0.70 | NOTUM (0.48) | ALDH1A1MAPTSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL9656115 | 0.69 | LMNA (0.62) | ALDH1A1MAPTSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL18539184 | 0.68 | MAPT (0.66) | ALDH1A1MAPTSMN1; SMN2KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200299270-A1 | PROTEOSTASIS REGULATORS | Kineta, Inc. | 2020-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200299270-A1 | PROTEOSTASIS REGULATORS | PSMG3, VCP, HSPA5 | ALDH1A1 3419/4885MAPT 577/4885SMN1; SMN2 595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.