Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 11/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 11/20 | 0.35 |
| ▸ | FDPS | P14324 | 4/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2162067 | 0.82 | — | — | |
| Tromethamine SCHEMBL8147253 | 0.79 | SMPD1 (0.33) | MEN1LMNAKMT2ASMPD1S1PR1 | |
| Tromethamine SCHEMBL31404437 | 0.76 | MEN1 (0.50) | MEN1LMNAKMT2ASMPD1S1PR1 | |
| Tromethamine SCHEMBL9425272 | 0.74 | MEN1 (0.48) | MEN1LMNAKMT2ASMPD1S1PR1 | |
| Tromethamine SCHEMBL1509014 | 0.72 | LMNA (0.67) | MEN1LMNAKMT2ASMPD1S1PR1 | |
| Tromethamine SCHEMBL7899122 | 0.72 | LMNA (0.67) | MEN1LMNAKMT2ASMPD1S1PR1 | |
| Clodronic Acid SCHEMBL9238841 | 0.72 | KMT2A (0.50) | MEN1LMNAKMT2ASMPD1FDPS | |
| Tromethamine SCHEMBL10930305 | 0.72 | LMNA (0.50) | MEN1LMNAKMT2ASMPD1S1PR1 | |
| Tromethamine SCHEMBL31404439 | 0.71 | S1PR1 (0.46) | MEN1LMNAKMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL11761781 | 0.71 | MEN1 (0.43) | MEN1LMNAKMT2AS1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 408 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118930836-B | Flame-retardant rigid foam polyether polyol and preparation method and application thereof | 万华化学（烟台）容威聚氨酯有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-120153017-A | Value chain return method for recovering unbound additives and depolymerizing polyurethane or polyisocyanurate rigid foams by extraction from the rigid foams | 巴斯夫欧洲公司 | 2025-06-13 | — | — | CN | claimed |
| CN-119708411-A | Flame-retardant low-density semi-rigid polyurethane foam, preparation method thereof and packaging material | 南京美思德新材料有限公司 | 2025-03-28 | — | — | CN | claimed |
| CN-119192530-A | Incombustible spraying polyurethane material for refrigeration house and preparation method thereof | 烟台市顺达聚氨酯有限责任公司 | 2024-12-27 | — | — | CN | claimed |
| CN-118930836-A | Flame-retardant rigid foam polyether polyol and preparation method and application thereof | 万华化学（烟台）容威聚氨酯有限公司 | 2024-11-12 | — | — | CN | claimed |
| CN-117534828-A | Diclofenac polyether ester monol and preparation method thereof, flame-retardant polyurethane foam and preparation method thereof | 万华化学（烟台）容威聚氨酯有限公司 | 2024-02-09 | — | — | CN | claimed |
| CN-116745084-A | Cellulose ester compositions and articles made therefrom | 国际人造丝公司 | 2023-09-12 | — | — | CN | claimed |
| CN-116715949-A | Polyurethane grouting reinforcement material with controllable curing reaction rate and high consolidation strength and preparation method thereof | 合肥工业大学 | 2023-09-08 | — | — | CN | claimed |
| CN-114854002-B | Para-toluenesulfonyl hydrazine polyether polyol and preparation method thereof, flame-retardant polyurethane foam and preparation method thereof | 万华化学（烟台）容威聚氨酯有限公司 | 2023-05-26 | — | — | CN | claimed |
| CN-116041649-A | Polyurethane hard foam composite material and preparation method thereof | 万华化学（烟台）容威聚氨酯有限公司 | 2023-05-02 | — | — | CN | claimed |
| CN-112143216-A | Polyurethane grouting reinforcement material and preparation method thereof | 陕西煤业化工技术研究院有限责任公司 | 2020-12-29 | — | — | CN | claimed |
| CN-112126212-A | Phosphorus-containing resin composition and articles made therefrom | 台光电子材料股份有限公司 | 2020-12-25 | — | — | CN | claimed |
| CN-111194329-A | Rigid polyurethane foams containing reactive flame retardants | 爱思乐-艾博美国有限公司 | 2020-05-22 | — | — | CN | claimed |
| CN-111057216-A | Single-component non-flammable polyurethane fireproof coating and preparation method thereof | 安徽三棵树涂料有限公司 | 2020-04-24 | — | — | CN | claimed |
| CN-111004607-A | Flame-retardant silane modified sealant and preparation and curing methods thereof | 上海东大化学有限公司 | 2020-04-14 | — | — | CN | claimed |
| CN-110628084-A | Modified graphite flame retardant, full-water-blown polyurethane foam prepared from flame retardant and preparation method of full-water-blown polyurethane foam | 威海云山科技有限公司 | 2019-12-31 | — | — | CN | claimed |
| CN-105658428-B | Antifogging composition and method for producing same | 塞拉尼斯醋酸纤维有限公司 | 2019-12-17 | — | — | CN | claimed |
| US-20170174861-A1 | POLYURETHANE FOAM FOR CONCRETE APPLICATIONS | CVETEZAR BRIAN ANTONE (US) | 2017-06-22 | — | — | US | claimed |
| US-20140193197-A1 | POLYURETHANE FOAM FOR CONCRETE APPLICATIONS | CVETEZAR BRIAN ANTONE (US) | 2014-07-10 | — | — | US | claimed |
| WO-2009114178-A2 | NATURAL OIL BASED HALOGENATED COMPOUNDS | BIOBASED TECHNOLOGIES, LLC (US) | 2009-09-17 | — | — | WO | claimed |