Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.30 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL1930620 | 0.79 | MEN1 (0.40) | SMPD1MEN1LMNAKMT2AS1PR1 | |
| SCHEMBL7044771 | 0.73 | — | — | |
| Tromethamine SCHEMBL31404437 | 0.68 | MEN1 (0.50) | SMPD1MEN1LMNAKMT2AS1PR1 | |
| SCHEMBL11661678 | 0.68 | — | — | |
| SCHEMBL6684304 | 0.67 | SMPD1 (0.33) | SMPD1 | |
| SCHEMBL11716827 | 0.67 | — | — | |
| Tromethamine SCHEMBL9425272 | 0.67 | MEN1 (0.48) | SMPD1MEN1LMNAKMT2AS1PR1 | |
| SCHEMBL10629017 | 0.66 | — | — | |
| Tromethamine SCHEMBL7899122 | 0.65 | LMNA (0.67) | SMPD1MEN1LMNAKMT2AS1PR1 | |
| Tromethamine SCHEMBL1509014 | 0.65 | LMNA (0.67) | SMPD1MEN1LMNAKMT2AS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0792911-A2 | Flame resistant polyolefin compositions | FMC CORPORATION (US) | 1997-09-03 | — | — | EP | claimed |
| WO-2000005304-A1 | METHOD FOR REDUCING ODOR DURING PROCESSING OF FLAME RETARDANT POLYMERS | GREAT LAKES CHEMICAL CORPORATION (US) | 2000-02-03 | — | — | WO | disclosed |
| EP-0792911-A2 | Flame resistant polyolefin compositions | FMC CORPORATION (US) | 1997-09-03 | — | — | EP | disclosed |