Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | FDPS | P14324 | 6/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL1509014 | 1.00 | LMNA (0.67) | LMNAMEN1KMT2AFDPSGRM4 | |
| Tromethamine SCHEMBL10930305 | 0.87 | LMNA (0.50) | LMNAMEN1KMT2AFDPSGRM4 | |
| Tromethamine SCHEMBL29366645 | 0.85 | KMT2A (0.56) | LMNAMEN1KMT2AFDPSGRM4 | |
| Tromethamine SCHEMBL7572662 | 0.85 | LMNA (0.56) | LMNAMEN1KMT2AFDPSGRM4 | |
| Tromethamine SCHEMBL29130482 | 0.83 | KMT2A (0.53) | LMNAMEN1KMT2AFDPSGRM4 | |
| Phosphoric Acid SCHEMBL11822162 | 0.83 | LMNA (0.45) | LMNAMEN1KMT2AFDPSGRM4 | |
| Tromethamine SCHEMBL975 | 0.82 | — | — | |
| Tromethamine SCHEMBL3696191 | 0.82 | — | — | |
| Tromethamine SCHEMBL17484 | 0.82 | MEN1 (1.00) | LMNAMEN1KMT2AS1PR1S1PR3 | |
| Tromethamine SCHEMBL2202687 | 0.81 | KMT2A (0.59) | LMNAMEN1KMT2AFDPSS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200791-B1 | Method of purifying thrombin-like protease enzymes obtained from snake venom | KNOLL AKTIENGESELLSCHAFT (DE) | 2001-03-13 | — | — | US | disclosed |