Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | MLYCD | O95822 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1932757 | 1.00 | CHRNA7 (0.39) | CHRNA7ESR1ESR2ACHETDP1 | |
| SCHEMBL307896 | 1.00 | CHRNA7 (0.39) | CHRNA7ESR1ESR2ACHETDP1 | |
| SCHEMBL14593355 | 0.87 | ESR1 (0.48) | ESR1ESR2NR1I2CES2CES1 | |
| SCHEMBL5755708 | 0.82 | CA2 (0.38) | CHRNA7ESR1ESR2ACHETDP1 | |
| SCHEMBL24408950 | 0.81 | PTPN5 (0.43) | ESR1ESR2NR1I2OGAKDM5B | |
| SCHEMBL24408977 | 0.81 | PTPN5 (0.43) | ESR1ESR2NR1I2OGAKDM5B | |
| SCHEMBL14701578 | 0.81 | PTPN5 (0.43) | ESR1ESR2NR1I2OGAKDM5B | |
| SCHEMBL2175953 | 0.78 | ESR1 (0.65) | ESR1ESR2TDP1CA2CA1 | |
| SCHEMBL1272903 | 0.78 | NR1I2 (0.41) | ESR1ESR2NR1I2CES2CES1 | |
| SCHEMBL1273068 | 0.78 | NR1I2 (0.41) | ESR1ESR2NR1I2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450532-B2 | Compounds useful in the preparation of tryptophan hydroxylase inhibitors | LEXICON PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450532-B2 | Compounds useful in the preparation of tryptophan hydroxylase inhibitors | LEXICON PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450532-B2 | Compounds useful in the preparation of tryptophan hydroxylase inhibitors | LEXICON PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-20110130564-A1 | COMPOUNDS USEFUL IN THE PREPARATION OF TRYPTOPHAN HYDRROXYLASE INHIBITORS | TERSERA THERAPEUTICS LLC | 2011-06-02 | — | — | US | disclosed |
| US-20110130564-A1 | COMPOUNDS USEFUL IN THE PREPARATION OF TRYPTOPHAN HYDRROXYLASE INHIBITORS | TERSERA THERAPEUTICS LLC | 2011-06-02 | — | — | US | disclosed |
| US-20110130564-A1 | COMPOUNDS USEFUL IN THE PREPARATION OF TRYPTOPHAN HYDRROXYLASE INHIBITORS | TERSERA THERAPEUTICS LLC | 2011-06-02 | — | — | US | disclosed |
| US-7897763-B2 | Process for the preparation of substituted phenylalanines | LEXICON PHARMACEUTICALS, INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-7897763-B2 | Process for the preparation of substituted phenylalanines | LEXICON PHARMACEUTICALS, INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-7897763-B2 | Process for the preparation of substituted phenylalanines | LEXICON PHARMACEUTICALS, INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-7855291-B2 | Process for the preparation of substituted phenylalanines | LEXICON PHARMACEUTICALS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-20090118505-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | TERSERA THERAPEUTICS LLC | 2009-05-07 | — | — | US | disclosed |
| US-20090118505-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | TERSERA THERAPEUTICS LLC | 2009-05-07 | — | — | US | disclosed |
| US-20090099206-A1 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| US-20090099206-A1 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| US-20090099206-A1 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| WO-2009048864-A1 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009048864-A1 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| US-20090048280-A1 | Process for the preparation of substituted phenylalanines | TERSERA THERAPEUTICS LLC | 2009-02-19 | — | — | US | disclosed |
| US-20090048280-A1 | Process for the preparation of substituted phenylalanines | TERSERA THERAPEUTICS LLC | 2009-02-19 | — | — | US | disclosed |
| US-20090048280-A1 | Process for the preparation of substituted phenylalanines | TERSERA THERAPEUTICS LLC | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130564-A1 | COMPOUNDS USEFUL IN THE PREPARATION OF TRYPTOPHAN HYDRROXYLASE INHIBITORS | TPH1, TPH2, PAH | CHRNA7 1977/4885ESR1 4674/4885ESR2 4526/4885 |
| US-20090099206-A1 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE | PCCA, ANXA6, CPS1 | CHRNA7 2836/4885ESR1 3923/4885ESR2 1361/4885 |
| US-20090118505-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | PAH, TYR, NPEPPS | CHRNA7 3118/4885ESR1 3868/4885ESR2 4138/4885 |
| US-20090048280-A1 | Process for the preparation of substituted phenylalanines | PAH, TYR, NPEPPS | CHRNA7 3118/4885ESR1 3868/4885ESR2 4138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.