Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 10/20 | 0.66 |
| ▸ | GAA | P10253 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.65 |
| ▸ | NPC1 | O15118 | 6/20 | 0.65 |
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | STAT1 | P42224 | 1/20 | 0.65 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.65 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.65 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | CCR6 | P51684 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | RXFP2 | Q8WXD0 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12129932 | 0.82 | NPC1 (0.78) | MAPTGAATDP1ALDH1A1NPC1 | |
| SCHEMBL9900412 | 0.81 | MAPT (0.69) | MAPTGAATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14096446 | 0.80 | ALDH1A1 (0.69) | MAPTGAATDP1ALDH1A1NPC1 | |
| SCHEMBL5837764 | 0.80 | ALDH1A1 (0.69) | MAPTGAATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3053989 | 0.78 | ALDH1A1 (0.80) | MAPTGAATDP1ALDH1A1NPC1 | |
| SCHEMBL19337602 | 0.77 | MAPT (0.63) | MAPTGAATDP1ALDH1A1NPC1 | |
| SCHEMBL827717 | 0.77 | TDP1 (0.67) | MAPTGAATDP1ALDH1A1ALOX12 | |
| SCHEMBL790152 | 0.77 | RAB9A (1.00) | MAPTGAATDP1ALDH1A1NPC1 | |
| SCHEMBL3053908 | 0.75 | ALDH1A1 (0.63) | MAPTGAATDP1ALDH1A1NPC1 | |
| SCHEMBL827645 | 0.75 | CCR2 (0.57) | CCR2MAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143419-B2 | Trisubstituted 1,2,4-triazoles | JANSSEN PHARMACEUTICA N. V. (BE) | 2012-03-27 | — | — | US | disclosed |
| US-8143419-B2 | Trisubstituted 1,2,4-triazoles | JANSSEN PHARMACEUTICA N. V. (BE) | 2012-03-27 | — | — | US | disclosed |
| US-20090253691-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-10-08 | — | — | US | disclosed |
| US-20090253691-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253691-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | CHRNA1, CHRNA5, CHRNA3 | CCR2 1239/4885MAPT 1731/4885GAA 3210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.