Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 6/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6682030 | 0.81 | OPRK1 (0.36) | OPRK1OPRD1OPRM1CYP3A4CYP2D6 | |
| SCHEMBL583655 | 0.79 | ALOX15 (0.44) | OPRK1OPRD1OPRM1CYP3A4CYP2D6 | |
| SCHEMBL8577511 | 0.77 | OPRK1 (0.36) | OPRK1OPRD1OPRM1CYP3A4CYP2D6 | |
| SCHEMBL583582 | 0.74 | LMNA (0.39) | OPRK1OPRD1OPRM1CYP3A4CYP2D6 | |
| SCHEMBL12289214 | 0.73 | KMT2A (0.34) | CYP2D6KDM4EMEN1KMT2AMAPT | |
| SCHEMBL21725120 | 0.72 | CTSS (0.41) | CYP3A4MEN1LMNAKMT2AALDH1A1 | |
| SCHEMBL19304 | 0.71 | TSHR (0.38) | OPRK1OPRD1OPRM1CYP3A4CYP2D6 | |
| SCHEMBL30148928 | 0.71 | CYP2C19 (0.44) | OPRK1OPRD1OPRM1CYP3A4CYP2D6 | |
| SCHEMBL31269742 | 0.70 | GPR119 (0.36) | CYP2D6KDM4EKMT2AMAPT | |
| SCHEMBL21380324 | 0.69 | GRM2 (0.33) | ALOX15LMNAMTORMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2506716-A1 | NOVEL TRICYCLIC COMPOUNDS | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068881-A1 | NOVEL TRICYCLIC COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |