Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 8/20 | 0.64 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 2/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | POLQ | O75417 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29465610 | 1.00 | RORC (0.64) | RORCPPARGCCR2MRGPRX4POLQ | |
| SCHEMBL28895765 | 0.92 | RORC (0.56) | RORCPPARGCCR2MRGPRX4POLQ | |
| SCHEMBL28285110 | 0.92 | RORC (0.55) | RORCPPARGCCR2MRGPRX4POLQ | |
| SCHEMBL28895622 | 0.90 | RORC (0.54) | RORCPPARGCCR2MRGPRX4POLQ | |
| SCHEMBL20822477 | 0.89 | RORC (0.52) | RORCPPARGMRGPRX4EPHX2PLA2G4A | |
| SCHEMBL28285097 | 0.88 | RORC (0.55) | RORCPPARGCCR2MRGPRX4POLQ | |
| SCHEMBL19360544 | 0.88 | RORC (0.65) | RORCPPARGMRGPRX4POLQEPHX2 | |
| SCHEMBL29465606 | 0.88 | RORC (0.65) | RORCPPARGMRGPRX4POLQEPHX2 | |
| SCHEMBL22238330 | 0.88 | RORC (0.51) | RORCPPARGCCR2MRGPRX4POLQ | |
| SCHEMBL22238305 | 0.87 | RORC (0.51) | RORCPPARGCCR2MRGPRX4POLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109963836-B | Deuterium atom substituted indole carboxamide derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-113227048-B | Crystal form of indole carboxamide derivative and preparation method thereof | 江苏恒瑞医药股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-113365980-B | Crystal form of deuterium atom substituted indole formamide derivative and preparation method thereof | 江苏恒瑞医药股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-113365980-A | Crystal form of deuterium atom substituted indole formamide derivative and preparation method thereof | 江苏恒瑞医药股份有限公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-109952298-B | Indole carboxamide derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-09-03 | — | — | CN | disclosed |
| CN-113227048-A | Crystal form of indole carboxamide derivative and preparation method thereof | 江苏恒瑞医药股份有限公司 | 2021-08-06 | — | — | CN | disclosed |
| CN-107531679-B | Aromatic amide derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-07-02 | — | — | CN | disclosed |
| WO-2020182109-A1 | CRYSTAL FORM OF DEUTERIUM ATOM-SUBSTITUTED INDOLE FORMAMIDE DERIVATIVE AND PREPARATION METHOD THEREFOR | 江苏恒瑞医药股份有限公司 | 2020-09-17 | — | — | WO | disclosed |
| US-20200277278-A1 | Deuterium Atom-Substituted Indole Formamide Derivative, Preparation Method Therefor, and Medical Applications Thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2020-09-03 | — | — | US | disclosed |
| US-20200277278-A1 | Deuterium Atom-Substituted Indole Formamide Derivative, Preparation Method Therefor, and Medical Applications Thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2020-09-03 | — | — | US | disclosed |
| EP-3683206-A1 | DEUTERIUM ATOM-SUBSTITUTED INDOLE FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL APPLICATIONS THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2020-07-22 | — | — | EP | disclosed |
| EP-3683206-A1 | DEUTERIUM ATOM-SUBSTITUTED INDOLE FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL APPLICATIONS THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2020-07-22 | — | — | EP | disclosed |
| WO-2020140960-A1 | CRYSTAL FORM FOR INDOLE-FORMAMIDE DERIVATIVE AND PREPARATION METHOD FOR CRYSTAL FORM | 江苏恒瑞医药股份有限公司 | 2020-07-09 | — | — | WO | disclosed |
| EP-3650448-A1 | INDOLE-FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2020-05-13 | — | — | EP | disclosed |
| US-20200131123-A1 | INDOLE-FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2020-04-30 | — | — | US | disclosed |
| WO-2019052440-A1 | DEUTERIUM ATOM-SUBSTITUTED INDOLE FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL APPLICATIONS THEREOF | 江苏恒瑞医药股份有限公司 | 2019-03-21 | — | — | WO | disclosed |
| WO-2019007382-A1 | INDOLE-FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | 江苏恒瑞医药股份有限公司 | 2019-01-10 | — | — | WO | disclosed |
| CN-107531679-A | Aromatic amides analog derivative, its preparation method and its application in medicine | 江苏恒瑞医药股份有限公司 | 2018-01-02 | — | — | CN | disclosed |
| WO-2017157332-A1 | AROMATIC AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATIONS THEREOF | 江苏恒瑞医药股份有限公司 | 2017-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200277278-A1 | Deuterium Atom-Substituted Indole Formamide Derivative, Preparation Method Therefor, and Medical Applications Thereof | RORA, RORB, RORC | RORC 3/4885PPARG 105/4885CCR2 2338/4885 |
| US-20200131123-A1 | INDOLE-FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | TPH1, TPH2, PAH | RORC 2084/4885PPARG 1967/4885CCR2 3910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.