Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 12/20 | 0.49 |
| ▸ | CES1 | P23141 | 11/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6834129 | 0.81 | HSD17B10 (0.48) | MAPTTDP1 | |
| Biphenyl SCHEMBL17969155 | 0.79 | HSD17B10 (0.46) | HDAC2MAPTTDP1 | |
| SCHEMBL3976631 | 0.74 | LTA4H (0.41) | MAPT | |
| SCHEMBL4849742 | 0.71 | ALDH1A1 (0.51) | MAPT | |
| SCHEMBL3619161 | 0.71 | MYC (0.53) | RAB9AMAPT | |
| SCHEMBL11312963 | 0.71 | CES2 (0.83) | CES2CES1RAB9AMAPT | |
| SCHEMBL3976718 | 0.71 | ALDH1A1 (0.40) | RAB9AMAPTTDP1 | |
| SCHEMBL17829925 | 0.70 | BCAT2 (0.56) | MAPT | |
| SCHEMBL4671318 | 0.70 | PDE4A (0.44) | HDAC2 | |
| SCHEMBL27775806 | 0.70 | MAPT (0.47) | HDAC2MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9763938-B2 | Substituted quinoxalines as positive allosteric modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2017-09-19 | — | — | US | disclosed |