Sugi Predict

Sugi Predict / Compounds / SCHEMBL1936291

SCHEMBL1936291

SCHEMBL1936291

[CH2]c1cccc(CN2CCCC2)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRMT6 Q96LA8 1/20 0.62
▸ SMN1; SMN2 Q16637 3/20 0.61
▸ ALDH1A1 P00352 3/20 0.61
▸ TDP1 Q9NUW8 1/20 0.61
▸ KDM4E B2RXH2 1/20 0.56
▸ GAA P10253 1/20 0.56
▸ CYP2D6 P10635 2/20 0.54
▸ CYP2C9 P11712 1/20 0.54
▸ HIF1A Q16665 1/20 0.54
▸ HRH3 Q9Y5N1 3/20 0.52
▸ CYP2C19 P33261 1/20 0.52
▸ MBTD1 Q05BQ5 1/20 0.49
▸ TP53BP1 Q12888 1/20 0.49
▸ L3MBTL3 Q96JM7 1/20 0.49
▸ L3MBTL1 Q9Y468 1/20 0.49
▸ POLB P06746 1/20 0.49
▸ CHRNB2 P17787 1/20 0.49
▸ CHRNA4 P43681 1/20 0.49
▸ HTT P42858 1/20 0.49
▸ SIGMAR1 Q99720 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2463939 0.98 ALDH1A1 (0.64) PRMT6SMN1; SMN2ALDH1A1TDP1KDM4E
SCHEMBL19582190 0.84 SIGMAR1 (0.62) PRMT6ALDH1A1TDP1CYP2C9HIF1A
SCHEMBL19581718 0.84 MC4R (0.62) PRMT6ALDH1A1KDM4EHRH3SIGMAR1
SCHEMBL2463951 0.84 NCF1 (0.66) PRMT6SMN1; SMN2ALDH1A1KDM4EHRH3
SCHEMBL11192726 0.84 PRMT6 (0.78) PRMT6SMN1; SMN2ALDH1A1TDP1KDM4E
SCHEMBL11339852 0.84 PRMT6 (0.78) PRMT6SMN1; SMN2ALDH1A1TDP1KDM4E
SCHEMBL2462639 0.81 ACHE (0.65) ALDH1A1KDM4EGAAHRH3MBTD1
SCHEMBL9325982 0.77 PRMT6 (0.68) PRMT6SMN1; SMN2ALDH1A1TDP1KDM4E
SCHEMBL15668030 0.77 ALDH1A1 (0.96) PRMT6SMN1; SMN2ALDH1A1TDP1KDM4E
SCHEMBL110832 0.77 PRMT6 (1.00) PRMT6SMN1; SMN2ALDH1A1TDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230132298-A1 OXABOROLE ESTERS AND USES THEREOF ANACOR PHARMACEUTICALS, LLC 2023-04-27 — — US claimed
US-11578087-B2 Oxaborole esters and uses thereof ANACOR PHARMACEUTICALS, INC. (US) 2023-02-14 — — US claimed
US-20210101916-A1 OXABOROLE ESTERS AND USES THEREOF ANACOR PHARMACEUTICALS, INC. 2021-04-08 — — US claimed
US-8044041-B2 e.g. 4-Chloro-1-hydroxy-phthalazine-6-carboxylic acid [4-chloro-3'-(2-dimethylamino-ethoxy)-biphenyl-3-yl]-amide; multifunctioning protein kinase inhibitors; anticarcinogenic, antiinflammatory, antidiabetic agent, neurodegenerative diseases FOREST LABORATORIES HOLDINGS LIMITED (BM) 2011-10-25 — — US claimed
EP-2131656-A2 PHTHALAZINE DERIVATIVES Forest Laboratories Holdings Limited (BM) 2009-12-16 — — EP claimed
US-20080146547-A1 PHTHALAZINE DERIVATIVES FOREST LABORATORIES HOLDINGS LIMITED (BM) 2008-06-19 — — US claimed
WO-2008061108-A2 PHTHALAZINE DERIVATIVES FOREST LABORATORIES HOLDINGS LIMITED (BM) 2008-05-22 — — WO claimed
US-20230132298-A1 OXABOROLE ESTERS AND USES THEREOF ANACOR PHARMACEUTICALS, LLC 2023-04-27 — — US disclosed
US-11578087-B2 Oxaborole esters and uses thereof ANACOR PHARMACEUTICALS, INC. (US) 2023-02-14 — — US disclosed
CN-115043840-A Methods for preparing TOLL-like receptor modulators 吉利德科学公司 2022-09-13 — — CN disclosed
CN-107074860-B Methods for preparing TOLL-like receptor modulators 吉利德科学公司 2022-07-15 — — CN disclosed
CN-113454086-A Imidazo [2,1-F ] [1,2,4] triazin-4-amine derivatives as TLR7 agonists 百济神州有限公司 2021-09-28 — — CN disclosed
CN-113423708-A Imidazo [2,1-F ] [1,2,4] triazin-4-amine derivatives as TLR7 agonists 百济神州有限公司 2021-09-21 — — CN disclosed
US-20110237571-A1 PHTHALAZINE DERIVATIVES ARALDI GIAN-LUCA 2011-09-29 — — US disclosed
EP-2331518-A1 NEW BRADYKININ B1 ANTAGONISTS Evotec AG (DE) 2011-06-15 — — EP disclosed
EP-2131656-A2 PHTHALAZINE DERIVATIVES Forest Laboratories Holdings Limited (BM) 2009-12-16 — — EP disclosed
US-20080146547-A1 PHTHALAZINE DERIVATIVES FOREST LABORATORIES HOLDINGS LIMITED (BM) 2008-06-19 — — US disclosed
WO-2008061108-A2 PHTHALAZINE DERIVATIVES FOREST LABORATORIES HOLDINGS LIMITED (BM) 2008-05-22 — — WO disclosed
US-4550118-A ANTIULCER, ANTISECRETORY AGENT, HISTAMINE ANTAGONIST IKEDA MOHANDO CO., LTD. (JP) 1985-10-29 — — US disclosed
EP-0111685-A1 Benzazoles as histamine H2 receptor antagonists Ikeda Mohando Co., Ltd. (JP) 1984-06-27 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110237571-A1 PHTHALAZINE DERIVATIVES CDK5, HIPK2, PACSIN2 PRMT6 1823/4885SMN1; SMN2 4449/4885ALDH1A1 3613/4885
US-20080146547-A1 PHTHALAZINE DERIVATIVES CDK5, HIPK2, PACSIN2 PRMT6 1823/4885SMN1; SMN2 4449/4885ALDH1A1 3613/4885
US-20230132298-A1 OXABOROLE ESTERS AND USES THEREOF OXA1L, HSD17B12, OXER1 PRMT6 3495/4885SMN1; SMN2 442/4885ALDH1A1 585/4885
US-20210101916-A1 OXABOROLE ESTERS AND USES THEREOF OXA1L, HSD17B12, OXER1 PRMT6 3495/4885SMN1; SMN2 442/4885ALDH1A1 585/4885
US-11578087-B2 Oxaborole esters and uses thereof OXA1L, HSD17B12, OXER1 PRMT6 3495/4885SMN1; SMN2 442/4885ALDH1A1 585/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.