Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365457 | 0.92 | MAPT (0.38) | CHRM4KDM1AHDAC1HDAC2MAPT | |
| SCHEMBL19365254 | 0.87 | HTR2C (0.47) | MAPTHTR2AHTR2CHTR2BTRPV1 | |
| SCHEMBL19365708 | 0.85 | MAPT (0.41) | KDM1AMAPTHTR2AHTR2CMAOA | |
| SCHEMBL19670418 | 0.85 | MPL (0.42) | CHRM4KDM1AMAPTMAOAMAOB | |
| SCHEMBL19365904 | 0.84 | MAPT (0.43) | MAPTTRPV1CA2CA9ALDH1A1 | |
| SCHEMBL17618421 | 0.84 | RPS6KB1 (0.39) | CHRM4KDM1AHDAC1HDAC2MAOA | |
| SCHEMBL19365595 | 0.83 | MAPT (0.38) | KDM1AMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL19365498 | 0.82 | HTR2C (0.46) | MAPTHTR2AHTR2CHTR2BTRPV1 | |
| SCHEMBL19365368 | 0.82 | TRPA1 (0.38) | KDM1AMAPTMAOAMAOBCA2 | |
| SCHEMBL19670246 | 0.81 | SCN9A (0.39) | KDM1AMAPTMAOAMAOBTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |