Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 6/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365433 | 0.92 | PDE10A (0.34) | TRPV3CNR1PLK4PRKCIALDH1A1 | |
| SCHEMBL19365678 | 0.92 | PDE10A (0.34) | TRPV3CNR1PLK4PRKCIALDH1A1 | |
| SCHEMBL19365545 | 0.90 | TEK (0.32) | TRPV3PLK4PRKCITEKALDH1A1 | |
| SCHEMBL19365440 | 0.89 | PIM2 (0.35) | ABL1 | |
| SCHEMBL19365744 | 0.89 | ABL1 (0.43) | ABL1BCRTEKJAK2ALDH1A1 | |
| SCHEMBL19365595 | 0.87 | MAPT (0.38) | JAK2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL19365418 | 0.87 | CLK2 (0.39) | TRPV3CNR1ABL1BCRKIT | |
| SCHEMBL19670365 | 0.86 | VCP (0.37) | TRPV3CNR1ABL1KITJAK2 | |
| SCHEMBL19670423 | 0.85 | TRPV3 (0.38) | TRPV3ABL1BCRPRKCITEK | |
| SCHEMBL17618495 | 0.84 | TRPV3 (0.37) | TRPV3CNR1ABL1BCRPRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |