Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PRKCI | P41743 | 1/20 | 0.30 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19364877 | 0.90 | TRPV3 (0.38) | TEKTRPV3SYKPLK4GSK3B | |
| SCHEMBL19670206 | 0.88 | DYRK1A (0.34) | SCN10ATRPV3GSK3BDYRK1A | |
| SCHEMBL19365431 | 0.88 | IDH1 (0.34) | TEKIDH1ALOX5APSYKCREBBP | |
| SCHEMBL19365678 | 0.88 | PDE10A (0.34) | TRPV3PLK4DYRK1AKDM4EALDH1A1 | |
| SCHEMBL19365433 | 0.88 | PDE10A (0.34) | TRPV3PLK4DYRK1AKDM4EALDH1A1 | |
| SCHEMBL19365380 | 0.86 | KARS1 (0.39) | TEKIDH1FAAHALOX5APSYK | |
| SCHEMBL17618549 | 0.86 | SCN10A (0.34) | TEKFAAHSCN10ATRPV3ALOX5AP | |
| SCHEMBL19365440 | 0.85 | PIM2 (0.35) | — | |
| SCHEMBL19365756 | 0.84 | VCP (0.38) | IDH1FAAHCREBBPGSK3BDYRK1A | |
| SCHEMBL19365595 | 0.83 | MAPT (0.38) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |